dc.contributor.author | Nagy Arnold | |
dc.contributor.author | Mátrai, Péter | |
dc.contributor.author | Hegyi, Péter | |
dc.contributor.author | Alizadeh, Hussain | |
dc.contributor.author | Bajor, Judit | |
dc.contributor.author | Czopf, László | |
dc.contributor.author | Gyöngyi, Zoltán | |
dc.contributor.author | Kiss, Zoltán | |
dc.contributor.author | Márta, Katalin | |
dc.contributor.author | Simon, Mária | |
dc.contributor.author | Szilágyi, Ágnes Lilla | |
dc.contributor.author | Veres, Gábor | |
dc.contributor.author | Mosdósi, Bernadett | |
dc.date.accessioned | 2019-07-08T11:31:45Z | |
dc.date.available | 2019-07-08T11:31:45Z | |
dc.date.issued | 2019 | |
dc.identifier | 85060128903 | |
dc.identifier.citation | journalVolume=17;journalIssueNumber=1; pagination=4, pages 11;journalTitle=PEDIATRIC RHEUMATOLOGY;journalAbbreviatedTitle=PEDIATR RHEUMATOL; | |
dc.identifier.uri | http://repo.lib.semmelweis.hu//handle/123456789/7071 | |
dc.identifier.uri | doi:10.1186/s12969-019-0305-x | |
dc.description.abstract | Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on the underlying symptoms of arthritis with an exclusion of other diseases Biologic agents are increasingly used on the side of disease-modifying anti-rheumatic drugs (DMARD) in JIA treatment.The aim of this meta-analysis was to investigate the observed infections in JIA children during tumor necrosis factor (TNF)-alpha inhibitor therapy. A systematic search of three databases (Medline via PubMed, Embase, Cochrane Library) was carried out up to May 2018. Published trials that evaluated the infectious adverse events in patients receiving TNF-alpha inhibitor vs. a control group were included in the analysis. Full-text data extraction was carried out independently by the investigators from ten relevant publications. 1434 patients received TNF-alpha inhibitor therapy; the control group consisted of 696 subjects. The analysis presented the risk of infection in the active treatment group (OR = 1.13; 95% CI: 0.76-1.69; p = 0.543). The majority of infections were upper respiratory tract infections (URTIs). Furthermore, the subgroup analysis demonstrated a higher infection rate in the observed localization.Anti-TNF therapy slightly but not significantly increases the incidence of infection in JIA children compared to other therapies (GRADE: moderate evidence). The most common infections reported were mild URTIs. Further studies with larger patients number with a strong evidence level are crucially needed to finalize the answer whether anti-TNF therapy elevates and if yes on what extent the incidence of infection in JIA children.Prospero: CRD42017067873 . | |
dc.relation.ispartof | urn:issn:1546-0096 | |
dc.title | The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children | |
dc.type | Journal Article | |
dc.date.updated | 2019-06-20T12:51:33Z | |
dc.language.rfc3066 | en | |
dc.rights.holder | NULL | |
dc.identifier.mtmt | 30403635 | |
dc.identifier.wos | 000456276500001 | |
dc.identifier.pubmed | 30658717 | |
dc.contributor.department | SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika | |
dc.contributor.institution | Semmelweis Egyetem | |
dc.mtmt.swordnote | Journal Article; Review Journal Article; Meta-Analysis; Review Funding Agency and Grant Number: Economic Development and Innovation Operative Programme Grant [EFOP-3.6.3-VEKOP-16-2017-00009]; National Research, Development and Innovation Office [GINOP 2.3.2-15-2016-00048] Funding text: This study was supported by EFOP-3.6.3-VEKOP-16-2017-00009 and an Economic Development and Innovation Operative Programme Grant (GINOP 2.3.2-15-2016-00048 to PH) from the National Research, Development and Innovation Office. The authors have no financial relationships to disclose relevant to this article. Department of Paediatrics, Medical School, University of Pécs, 7. József Attila street, Pécs, 7623, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Momentum Gastroenterology Multidisciplinary Research Group, Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary Division of Haematology, First Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary Division of Cardiology, First Department of Internal Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary First Department of Paediatrics, Semmelweis University, Budapest, Hungary Institute for Trans. Medicine, Medical School, University of Pecs, Pécs, Hungary Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary Department of Psychiatry and Psychotherapy, Medical School, University of Pécs, Pécs, Hungary Institute of Surgical Research, University of Szeged, Szeged, Hungary Department of Paediatrics, Medical School, University of Debrecen, Debrecen, Hungary |