The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases

dc.contributor.author	Maria, Luisa Cayuela
dc.contributor.author	Kathleen, B. M. Claes
dc.contributor.author	Miguel, Godinho Ferreira
dc.contributor.author	Catarina, Martins Henriques
dc.contributor.author	Fredericus, van Eeden
dc.contributor.author	Máté, Varga
dc.contributor.author	Jeroen, Vierstraete
dc.contributor.author	Maria, Caterina Mione
dc.date.accessioned	2019-08-27T07:44:33Z
dc.date.available	2019-08-27T07:44:33Z
dc.date.issued	2019
dc.identifier.citation	journalVolume=6;pagination=178, pages: 9;journalTitle=FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY;journalAbbreviatedTitle=FRONT CELL DEV BIOL;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/7073
dc.identifier.uri	doi:10.3389/fcell.2018.00178
dc.description.abstract	Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.
dc.relation.ispartof	urn:issn:2296-634X
dc.title	The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
dc.type	Journal Article
dc.date.updated	2019-06-20T12:56:04Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	30411592
dc.contributor.department	SE/AOK/K/ISZGYK/MTA-SE Lendület Nephrogenetikai Kutatócsoport
dc.contributor.institution	Semmelweis Egyetem