dc.contributor.author |
Géczi, Zoltán |
|
dc.contributor.author |
Hermann, Péter |
|
dc.contributor.author |
Kőhidai, László |
|
dc.contributor.author |
Láng, Orsolya |
|
dc.contributor.author |
Kőhidai, Zsófia |
|
dc.contributor.author |
Mészáros, Tamás |
|
dc.contributor.author |
Barócsi, Attila |
|
dc.contributor.author |
Lenk, Sándor |
|
dc.contributor.author |
Zelles, Tivadar |
|
dc.date.accessioned |
2020-03-12T12:44:05Z |
|
dc.date.available |
2020-03-12T12:44:05Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
journalVolume=2018;journalIssueNumber=1;pagination=1048734, pages: 9;journalTitle=JOURNAL OF NANOMATERIALS;journalAbbreviatedTitle=J NANOMATER; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7128 |
|
dc.identifier.uri |
doi:10.1155/2018/1048734 |
|
dc.description.abstract |
To prepare an antimicrobial polymer composite composed of silver- (Ag-) polyethyleneimine- (PEI-) polylactic acid (PLA) in chloroform, for coating the mucosal surfaces of methacrylate-based dentures as a prospective therapy for denture stomatitis. The water-insoluble, tightly bound, hard, micrometre-thin, and colourless film exerts its effects by direct contact with the pathogens and via the active constituents (Ag, PEI, and Ag-PEI) released slowly into the mucosa’s salivary layer. Silver and PEI were blended at 140°C, then bound to PLA. The Ag-PEI complex was characterised by dynamic light scattering and transmission electron microscopy, and the Ag-PEI-PLA composite was examined by atomic force microscopy and micro-computed tomography. The characteristic was measured by atomic force microscopy (AFM) and micro-computed tomography (micro-CT). The quantity of water-soluble Ag-PEI complex released from the composite film was measured with gravimetry. The cellular physiological effects were analysed by impedimetry and computer-based morphometry using human gingival epithelial cells. A real-time cell proliferation assay revealed moderate toxic effects of Ag-PEI on the epithelium. The viscous Ag-PEI-PLA solution produced could be applied as a thin film on methacrylate surfaces. Active antimicrobial components (Ag, PEI, and Ag-PEI) were released from the hard, tightly bound Ag-PEI-PLA coating. This study’s findings verified the applicability of the antimicrobial Ag-PEI-PLA composite for coating the inner surfaces of acrylate dentures. Owing to the well-known antimicrobial effects of silver and PEI and the supplementary effects of chloroform, this composite provides a new therapeutic method for denture stomatitis that can be easily performed by dentists. |
|
dc.relation.ispartof |
urn:issn:1687-4110 |
|
dc.title |
Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-07-02T18:56:41Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30421328 |
|
dc.identifier.wos |
000450775000001 |
|
dc.contributor.department |
SE/FOK/Fogpótlástani Klinika |
|
dc.contributor.department |
SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet |
|
dc.contributor.department |
SE/FOK/Orális Diagnosztikai Tanszék |
|
dc.contributor.department |
SE/AOK/I/Kórélettani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|