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dc.contributor.author Jensen, TM
dc.contributor.author Witte, DR
dc.contributor.author Pieragostino, D
dc.contributor.author McGuire, JN
dc.contributor.author Schjerning, ED
dc.contributor.author Nardi, C
dc.contributor.author Urbani, A
dc.contributor.author Kivimaki, M
dc.contributor.author Brunner, EJ
dc.contributor.author Tabák, Ádám
dc.contributor.author Vistisen, D
dc.date.accessioned 2021-08-31T08:21:24Z
dc.date.available 2021-08-31T08:21:24Z
dc.date.issued 2013
dc.identifier 84885433330
dc.identifier.citation journalVolume=50;journalIssueNumber=5;journalTitle=ACTA DIABETOLOGICA;pagerange=697-704;journalAbbreviatedTitle=ACTA DIABETOL;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7156
dc.identifier.uri doi:10.1007/s00592-012-0376-3
dc.description.abstract Understanding early determinants of type 2 diabetes is essential for refining disease prevention strategies. Proteomic technology may provide a useful approach to identify novel protein patterns potentially related to pathophysiological changes that lead up to diabetes. In this study, we sought to identify protein signals that are associated with diabetes incidence in a middle-aged population. Serum samples from 519 participants in a nested case-control selection (167 cases and 352 age-, sex- and BMI-matched normoglycemic control subjects, median follow-up 14.0 years) within the Whitehall-II cohort were analyzed by linear matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Nine protein peaks were found to be associated with incident diabetes. Rate ratios for high peak intensity ranged between 0.4 (95% CI, 0.2-0.8) and 4.0 (95% CI, 1.7-9.2) and were robust to adjustment for main potential confounders, including obesity, lipids and C-reactive protein. The proteins associated with these peaks may reflect diabetes pathogenesis. Our study exemplifies the utility of an approach that combines proteomic and epidemiological data.
dc.format.extent 697-704
dc.relation.ispartof urn:issn:0940-5429
dc.title Association between protein signals and type 2 diabetes incidence
dc.type Journal Article
dc.date.updated 2019-07-05T09:26:17Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 1986325
dc.identifier.wos 000325026900006
dc.identifier.pubmed 22310914
dc.contributor.department SE/AOK/K/I. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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