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dc.contributor.author Téglási, Vanda
dc.contributor.author Csűry, Dániel T
dc.contributor.author Dezső, Katalin
dc.contributor.author Bugyik, Edina
dc.contributor.author Szabó, Vanessza
dc.contributor.author Szállási, Zoltán
dc.contributor.author Paku, Sándor
dc.contributor.author Reiniger, Lilla
dc.date.accessioned 2020-06-05T08:03:33Z
dc.date.available 2020-06-05T08:03:33Z
dc.date.issued 2019
dc.identifier.citation journalVolume=78;journalIssueNumber=4;journalTitle=JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY;pagerange=326-339;journalAbbreviatedTitle=J NEUROPATH EXP NEUR;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7232
dc.identifier.uri doi:10.1093/jnen/nlz007
dc.description.abstract The impact of growth pattern on the distribution of connective tissue and on the vascularization of brain metastases (40 colon, lung and breast carcinoma samples) was analyzed. Most of the cases showed either a "pushing-type" (18/40, mostly colon and lung carcinomas) or a "papillary-type" (19/40, mostly breast carcinomas) growth pattern. There was a striking difference in the growth pattern and vascularization of colon/lung versus breast carcinoma metastases. Pushing-type brain metastases incorporated fewer vessels and accumulated more collagen in the adjacent brain parenchyma, whereas papillary-type brain metastases incorporated more vessels and accumulated collagen in the center of the tumor. We observed duplication of the PDGFRβ-positive pericyte layer accompanied by an increase in the amount of collagen within the vessel walls. The outer layer of pericytes and the collagen was removed from the vessel by invasive activity of the tumors, which occurred either peri- or intratumorally, depending on the growth pattern of the metastasis. Our findings suggest that pericytes are the main source of the connective tissue in brain metastases. Vascularization and connective tissue accumulation of the brain metastases largely depend on the growth pattern of the tumors.
dc.format.extent 326-339
dc.relation.ispartof urn:issn:0022-3069
dc.title Origin and Distribution of Connective Tissue and Pericytes Impacting Vascularization in Brain Metastases With Different Growth Patterns
dc.type Journal Article
dc.date.updated 2019-07-16T10:37:47Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30548275
dc.identifier.wos 000463812800006
dc.identifier.pubmed 30816955
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.department SE/AOK/I/IISZPI/MTA-SE-NAP B Agymetasztázis Kutatócsoport
dc.contributor.institution Semmelweis Egyetem


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