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dc.contributor.author Madách Krisztina
dc.contributor.author Aladzsity István
dc.contributor.author Szilágyi Ágnes
dc.contributor.author Füst György
dc.contributor.author Gál János
dc.contributor.author Pénzes István
dc.contributor.author Prohászka Zoltán
dc.date.accessioned 2014-12-10T17:40:30Z
dc.date.available 2014-12-10T17:40:30Z
dc.date.issued 2010
dc.identifier 77951586510
dc.identifier.citation pagination=R79; journalVolume=14; journalIssueNumber=2; journalTitle=CRITICAL CARE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/733
dc.identifier.uri doi:10.1186/cc8992
dc.description.abstract Introduction: Activation of inflammation and coagulation are closely related and mutually interdependent in sepsis. The acute-phase protein, plasminogen activator inhibitor-1 (PAI-1) is a key element in the inhibition of fibrinolysis. Elevated levels of PAI-1 have been related to worse outcome in pneumonia. We aimed to evaluate the effect of functionally relevant 4G/5G polymorphism of PAI-1 gene in pneumonia induced sepsis. Methods: We enrolled 208 Caucasian patients with severe sepsis due to pneumonia admitted to an intensive care unit (ICU). Patients were followed up until ICU discharge or death. Clinical data were collected prospectively and the PAI-1 4G/5G polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism technique. Patients were stratified according to the occurrence of multiple organ dysfunction syndrome, septic shock or death. Results: We found that carriers of the PAI-1 4G/4G and 4G/5G genotypes have a 2.74-fold higher risk for multiple organ dysfunction syndrome (odds ratio [OR] 95% confidence interval [CI] = 1.335 -5.604; p = 0.006) and a 2.57-fold higher risk for septic shock (OR 95% CI = 1.180 - 5.615; p = 0.018) than 5G/5G carriers. The multivariate logistic regression analysis adjusted for independent predictors, such as age, nosocomial pneumonia and positive microbiological culture also supported that carriers of the 4G allele have a higher prevalence of multiple organ dysfunction syndrome (adjusted odds ratio [aOR] = 2.957; 95% CI = 1.306 -6.698; p = 0.009) and septic shock (aOR = 2.603; 95% CI = 1.137 - 5.959; p = 0.024). However, genotype and allele analyses have not shown any significant difference regarding mortality in models non- adjusted or adjusted for acute physiology and chronic health evaluation (APACHE) II. Patients bearing the 4G allele had higher disseminated intravascular coagulation (DIC) score at admission (p = 0.007) than 5G/5G carriers. Moreover, in 4G allele carriers the length of ICU stay of non-survivors was longer (p = 0.091), fewer ventilation-free days (p = 0.008) and days without septic shock (p = 0.095) were observed during the first 28 days. Conclusions: In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on continuous clinical variables.
dc.relation.ispartof urn:issn:1364-8535
dc.title 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study
dc.type Journal Article
dc.date.updated 2014-12-10T15:48:18Z
dc.language.rfc3066 en
dc.identifier.mtmt 1414727
dc.identifier.wos 000278816800053
dc.identifier.pubmed 20429897
dc.contributor.department SE/ÁOK/K/Aneszteziológiai és Intenzív Terápiás Klinika
dc.contributor.department SE/ÁOK/K/III. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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