Biomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study

Biomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study

Herder, C; Faerch, K; Carstensen-Kirberg, M; Lowe, GD; Haapakoski, R; Witte, DR; Brunner, EJ; Roden, M; Tabák, Ádám; Kivimaki, M; Vistisen, D

Folyóiratcikk

EUROPEAN JOURNAL OF ENDOCRINOLOGY vol.:175, issue.:5, p.:367-377.

ISSN: 0804-4643 1479-683X

URI: http://repo.lib.semmelweis.hu//handle/123456789/7364
https://doi.org/10.1530/EJE-16-0528

MTMT azonosító: 3161692

WoS ID: 000386913600007

Scopus ID: 84991384213

PubMed ID: 27491375

Megjelenés éve: 2016

Kivonat:

Objective: Higher systemic levels of pro-inflammatory biomarkers and low adiponectin are associated with increased risk of type 2 diabetes, but their associations with changes in glycaemic deterioration before onset of diabetes are poorly understood. We aimed to study whether inflammation-related biomarkers are associated with 5-year changes in glucose and insulin, HbA1c, insulin sensitivity and beta-cell function before the diagnosis of type 2 diabetes and whether these associations may be bidirectional.

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