dc.contributor.author |
Aigner, Petra |
|
dc.contributor.author |
Mizutani, Tatsuaki |
|
dc.contributor.author |
Horvath, Jaqueline |
|
dc.contributor.author |
Eder, Thomas |
|
dc.contributor.author |
Heber, Stefan |
|
dc.contributor.author |
Lind, Karin |
|
dc.contributor.author |
Just, Valentin |
|
dc.contributor.author |
Moll, Herwig P |
|
dc.contributor.author |
Yeroslaviz, Assa |
|
dc.contributor.author |
Fischer, Michael J M |
|
dc.contributor.author |
Kenner, Lukas |
|
dc.contributor.author |
Győrffy, Balázs |
|
dc.contributor.author |
Sill, Heinz |
|
dc.contributor.author |
Grebien, Florian |
|
dc.contributor.author |
Moriggl, Richard |
|
dc.contributor.author |
Casanova, Emilio |
|
dc.contributor.author |
Stoiber, Dagmar |
|
dc.date.accessioned |
2020-03-25T10:21:19Z |
|
dc.date.available |
2020-03-25T10:21:19Z |
|
dc.date.issued |
2019 |
|
dc.identifier.citation |
journalVolume=3;journalIssueNumber=13;journalTitle=BLOOD ADVANCES;pagerange=1989-2002;journalAbbreviatedTitle=BLOOD ADVANCES; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7464 |
|
dc.identifier.uri |
doi:10.1182/bloodadvances.2018026385 |
|
dc.description.abstract |
Signal transducer and activator of transcription 3 (STAT3) exists in 2 alternatively spliced isoforms, STAT3α and STAT3β. Although truncated STAT3β was originally postulated to act as a dominant-negative form of STAT3α, it has been shown to have various STAT3α-independent regulatory functions. Recently, STAT3β gained attention as a powerful antitumorigenic molecule in cancer. Deregulated STAT3 signaling is often found in acute myeloid leukemia (AML); however, the role of STAT3β in AML remains elusive. Therefore, we analyzed the STAT3β/α messenger RNA (mRNA) expression ratio in AML patients, where we observed that a higher STAT3β/α mRNA ratio correlated with a favorable prognosis and increased overall survival. To gain better understanding of the function of STAT3β in AML, we engineered a transgenic mouse allowing for balanced Stat3β expression. Transgenic Stat3β expression resulted in decelerated disease progression and extended survival in PTEN- and MLL-AF9-dependent AML mouse models. Our findings further suggest that the antitumorigenic function of STAT3β depends on the tumor-intrinsic regulation of a small set of significantly up- and downregulated genes, identified via RNA sequencing. In conclusion, we demonstrate that STAT3β plays an essential tumor-suppressive role in AML. |
|
dc.format.extent |
1989-2002 |
|
dc.relation.ispartof |
urn:issn:2473-9529 |
|
dc.title |
STAT3β is a tumor suppressor in acute myeloid leukemia |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-08-14T05:05:37Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30757817 |
|
dc.identifier.wos |
000474653700008 |
|
dc.identifier.pubmed |
31270081 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|