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dc.contributor.author Hamadeh, Lina
dc.contributor.author Enshaei, Amir
dc.contributor.author Schwab, Claire
dc.contributor.author Alonso, Cristina N
dc.contributor.author Attarbaschi, Andishe
dc.contributor.author Barbany, Gisela
dc.contributor.author den Boer, Monique L
dc.contributor.author Boer, Judith M
dc.contributor.author Braun, Marcin
dc.contributor.author Dalla Pozza, Luciano
dc.contributor.author Elitzur, Sarah
dc.contributor.author Emerenciano, Mariana
dc.contributor.author Fechina, Larisa
dc.contributor.author Felice, Maria Sara
dc.contributor.author Fronkova, Eva
dc.contributor.author Haltrich, Irén
dc.contributor.author Heyman, Mats M
dc.contributor.author Horibe, Keizo
dc.contributor.author Imamura, Toshihiko
dc.contributor.author Jeison, Marta
dc.contributor.author Kovács, Gábor
dc.contributor.author Kuiper, Roland P
dc.contributor.author Mlynarski, Wojciech
dc.contributor.author Nebral, Karin
dc.contributor.author Ivanov Öfverholm, Ingegerd
dc.contributor.author Pastorczak, Agata
dc.contributor.author Pieters, Rob
dc.contributor.author Piko, Henriett
dc.contributor.author Pombo-de-Oliveira, Maria S
dc.contributor.author Rubio, Patricia
dc.contributor.author Strehl, Sabine
dc.contributor.author Stary, Jan
dc.contributor.author Sutton, Rosemary
dc.contributor.author Trka, Jan
dc.contributor.author Tsaur, Grigory
dc.contributor.author Venn, Nicola
dc.contributor.author Vora, Ajay
dc.contributor.author Yano, Mio
dc.contributor.author Harrison, Christine J
dc.contributor.author Moorman, Anthony V
dc.date.accessioned 2020-09-10T06:36:57Z
dc.date.available 2020-09-10T06:36:57Z
dc.date.issued 2019
dc.identifier.citation journalVolume=3;journalIssueNumber=2;journalTitle=BLOOD ADVANCES;pagerange=148-157;journalAbbreviatedTitle=BLOOD ADVANCES;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7482
dc.identifier.uri doi:10.1182/bloodadvances.2018025718
dc.description.abstract Genetic abnormalities provide vital diagnostic and prognostic information in pediatric acute lymphoblastic leukemia (ALL) and are increasingly used to assign patients to risk groups. We recently proposed a novel classifier based on the copy-number alteration (CNA) profile of the 8 most commonly deleted genes in B-cell precursor ALL. This classifier defined 3 CNA subgroups in consecutive UK trials and was able to discriminate patients with intermediate-risk cytogenetics. In this study, we sought to validate the United Kingdom ALL (UKALL)-CNA classifier and reevaluate the interaction with cytogenetic risk groups using individual patient data from 3239 cases collected from 12 groups within the International BFM Study Group. The classifier was validated and defined 3 risk groups with distinct event-free survival (EFS) rates: good (88%), intermediate (76%), and poor (68%) (P < .001). There was no evidence of heterogeneity, even within trials that used minimal residual disease to guide therapy. By integrating CNA and cytogenetic data, we replicated our original key observation that patients with intermediate-risk cytogenetics can be stratified into 2 prognostic subgroups. Group A had an EFS rate of 86% (similar to patients with good-risk cytogenetics), while group B patients had a significantly inferior rate (73%, P < .001). Finally, we revised the overall genetic classification by defining 4 risk groups with distinct EFS rates: very good (91%), good (81%), intermediate (73%), and poor (54%), P < .001. In conclusion, the UKALL-CNA classifier is a robust prognostic tool that can be deployed in different trial settings and used to refine established cytogenetic risk groups.
dc.format.extent 148-157
dc.relation.ispartof urn:issn:2473-9529
dc.title Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL
dc.type Journal Article
dc.date.updated 2019-08-16T06:25:19Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30420807
dc.identifier.wos 000458435200009
dc.identifier.pubmed 30651283
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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