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dc.contributor.author Pawlak, John B
dc.contributor.author Bálint, László
dc.contributor.author Lim, Lillian
dc.contributor.author Ma, Wanshu
dc.contributor.author Davis, Reema B
dc.contributor.author Benyó, Zoltán
dc.contributor.author Soares, Michael J
dc.contributor.author Oliver, Guillermo
dc.contributor.author Kahn, Mark L
dc.contributor.author Jakus, Zoltán
dc.contributor.author Caron, Kathleen M
dc.date.accessioned 2021-10-13T13:01:22Z
dc.date.available 2021-10-13T13:01:22Z
dc.date.issued 2019
dc.identifier.citation journalVolume=129;journalIssueNumber=11;journalTitle=JOURNAL OF CLINICAL INVESTIGATION;pagerange=4912-4921;journalAbbreviatedTitle=J CLIN INVEST;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7561
dc.identifier.uri doi:10.1172/JCI120446
dc.description.abstract Molecular heterogeneity of endothelial cells underlies their highly-specialized functions during changing physiological conditions within diverse vascular beds. For example, placental spiral arteries (SAs) undergo remarkable remodeling to meet the ever-growing demands of the fetus-a process which is deficient in preeclampsia. The extent to which maternal endothelial cells coordinate with immune cells and pregnancy hormones to promote SA remodeling remains largely unknown. Here we found that remodeled SAs expressed the lymphatic markers PROX1, LYVE1, and VEGFR3, mimicking lymphatic identity. Uterine natural killer (uNK) cells, which are required for SA remodeling and secrete VEGFC, were both sufficient and necessary for VEGFR3 activation in vitro and in mice lacking uNK cells, respectively. Using Flt4Chy/+ mice with kinase inactive VEGFR3 and Vegfcfl/fl;Vav1-Cre mice, we demonstrated that SA remodeling required VEGFR3 signaling, and that disrupted maternal VEGFR3 signaling contributed to late-gestation fetal growth restriction. Collectively, we identified a novel instance of lymphatic mimicry by which maternal endothelial cells promote SA remodeling, furthering our understanding of the vascular heterogeneity employed for the mitigation of pregnancy complications such as fetal growth restriction and preeclampsia.
dc.relation.ispartof urn:issn:0021-9738; 1558-8238
dc.title Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling
dc.type Journal Article
dc.date.updated 2019-08-29T13:23:04Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30767578
dc.identifier.pubmed 31415243
dc.contributor.department SE/AOK/I/ÉI/MTA-SE Lendület Nyirokélettani Kutatócsoport
dc.contributor.department SE/KSZE/Klinikai Kísérleti Kutató Intézet
dc.contributor.department SE/AOK/I/Transzlációs Medicina Intézet
dc.contributor.institution Semmelweis Egyetem


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