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dc.contributor.author Odler, Balázs
dc.contributor.author Ivancsó, István
dc.contributor.author Somogyi, V
dc.contributor.author Benke, Kálmán
dc.contributor.author Tamási, Lilla
dc.contributor.author Gálffy, Gabriella
dc.contributor.author Szalay, Balázs
dc.contributor.author Müller, Veronika
dc.date.accessioned 2019-11-25T07:52:14Z
dc.date.available 2019-11-25T07:52:14Z
dc.date.issued 2015
dc.identifier 84942777657
dc.identifier.citation journalVolume=10;journalIssueNumber=1;journalTitle=INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE;pagerange=2017-2025;journalAbbreviatedTitle=INT J CHRONIC OBSTR;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7562
dc.identifier.uri doi:10.2147/COPD.S91654
dc.description.abstract INTRODUCTION: The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown. AIM: Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters. METHODS: A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients. RESULTS: The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86+/-1.79 ng/mL and 14.27+/-1.88 ng/mL vs 25.66+/-1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group. CONCLUSION: Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.
dc.format.extent 2017-2025
dc.relation.ispartof urn:issn:1176-9106
dc.title Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients
dc.type Journal Article
dc.date.updated 2019-09-02T09:22:46Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 2973023
dc.identifier.wos 000362298700001
dc.identifier.pubmed 26451099
dc.contributor.department SE/AOK/I/Laboratóriumi Medicina Intézet
dc.contributor.department SE/AOK/K/Pulmonológiai Klinika
dc.contributor.institution Semmelweis Egyetem


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