Amikacin containing self-emulsifying delivery systems via pulmonary administration for treatment of bacterial infections of cystic fibrosis patients.

dc.contributor.author	Hetenyi, G
dc.contributor.author	Griesser, J
dc.contributor.author	Fontana, S
dc.contributor.author	Gutierrez, AM
dc.contributor.author	Ellemunter, H
dc.contributor.author	Niedermayr, K
dc.contributor.author	Szabó, Péter
dc.contributor.author	Bernkop-Schnurch, A
dc.date.accessioned	2019-10-02T19:33:25Z
dc.date.available	2019-10-02T19:33:25Z
dc.date.issued	2018
dc.identifier.citation	journalVolume=13;journalIssueNumber=7;journalTitle=NANOMEDICINE;pagerange=717-732;journalAbbreviatedTitle=NANOMEDICINE-UK;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/7760
dc.identifier.uri	doi:10.2217/nnm-2017-0307
dc.description.abstract	AIM: The aim of the study was to develop self-emulsifying delivery systems (SEDDS) exhibiting improved permeation rate for pulmonary delivery of amikacin for treatment of cystic fibrosis (CF) patients. MATERIALS & METHODS: Solubility of amikacin in lipids was improved by hydrophobic ion pairing with sodium myristyl sulfate. The complex was loaded into SEDDS. Drug-release studies were performed and the permeation properties of SEDDS through human CF mucus were examined. RESULTS: A total of 10% complex could be loaded into SEDDS. SEDDS exhibited sustained release. Up to twofold more amounts of amikacin permeated through the CF mucus compared with reference. CONCLUSION: The developed SEDDS with amikacin may be a promising tool for the treatment of certain bacterial infections of CF patients.
dc.format.extent	717-732
dc.title	Amikacin containing self-emulsifying delivery systems via pulmonary administration for treatment of bacterial infections of cystic fibrosis patients.
dc.type	Journal Article
dc.date.updated	2019-09-15T14:56:01Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	3352190
dc.identifier.wos	000432823900005
dc.identifier.pubmed	29488425
dc.contributor.department	SE/GYTK/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet
dc.contributor.institution	Semmelweis Egyetem