dc.contributor.author |
Hetenyi, G |
|
dc.contributor.author |
Griesser, J |
|
dc.contributor.author |
Fontana, S |
|
dc.contributor.author |
Gutierrez, AM |
|
dc.contributor.author |
Ellemunter, H |
|
dc.contributor.author |
Niedermayr, K |
|
dc.contributor.author |
Szabó, Péter |
|
dc.contributor.author |
Bernkop-Schnurch, A |
|
dc.date.accessioned |
2019-10-02T19:33:25Z |
|
dc.date.available |
2019-10-02T19:33:25Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
journalVolume=13;journalIssueNumber=7;journalTitle=NANOMEDICINE;pagerange=717-732;journalAbbreviatedTitle=NANOMEDICINE-UK; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7760 |
|
dc.identifier.uri |
doi:10.2217/nnm-2017-0307 |
|
dc.description.abstract |
AIM: The aim of the study was to develop self-emulsifying delivery systems (SEDDS) exhibiting improved permeation rate for pulmonary delivery of amikacin for treatment of cystic fibrosis (CF) patients. MATERIALS & METHODS: Solubility of amikacin in lipids was improved by hydrophobic ion pairing with sodium myristyl sulfate. The complex was loaded into SEDDS. Drug-release studies were performed and the permeation properties of SEDDS through human CF mucus were examined. RESULTS: A total of 10% complex could be loaded into SEDDS. SEDDS exhibited sustained release. Up to twofold more amounts of amikacin permeated through the CF mucus compared with reference. CONCLUSION: The developed SEDDS with amikacin may be a promising tool for the treatment of certain bacterial infections of CF patients. |
|
dc.format.extent |
717-732 |
|
dc.title |
Amikacin containing self-emulsifying delivery systems via pulmonary administration for treatment of bacterial infections of cystic fibrosis patients. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-09-15T14:56:01Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
3352190 |
|
dc.identifier.wos |
000432823900005 |
|
dc.identifier.pubmed |
29488425 |
|
dc.contributor.department |
SE/GYTK/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|