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dc.contributor.author Kovacs, Andrea
dc.contributor.author Kiss, Mate
dc.contributor.author Pinter, Nandor
dc.contributor.author Szirmai, Imre
dc.contributor.author Kamondi, Anita
dc.date.accessioned 2019-10-26T16:57:36Z
dc.date.available 2019-10-26T16:57:36Z
dc.date.issued 2019
dc.identifier.citation journalVolume=18;journalIssueNumber=4;journalTitle=CEREBELLUM;pagerange=705-720;journalAbbreviatedTitle=CEREBELLUM;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/7934
dc.identifier.uri doi:10.1007/s12311-019-01027-3
dc.description.abstract It is a clinical experience that acute lesions of the cerebellum induce pathological tremor, which tends to improve. However, quantitative characteristics, imaging correlates, and recovery of cerebellar tremor have not been systematically investigated. We studied the prevalence, quantitative parameters measured with biaxial accelerometry, and recovery of pathological tremor in 68 patients with lesions affecting the cerebellum. We also investigated the correlation between the occurrence and characteristics of tremor and lesion localization using 3D T1-weighted MRI images which were normalized and segmented according to a spatially unbiased atlas template for the cerebellum. Visual assessment detected pathological tremor in 19% while accelerometry in 47% of the patients. Tremor was present both in postural and intentional positions, but never at rest. Two types of pathological tremor were distinguished: (1) low-frequency tremor in 36.76% of patients (center frequency 2.66 +/- 1.17 Hz) and (2) normal frequency-high-intensity tremor in 10.29% (center frequency 8.79 +/- 1.43 Hz). The size of the lesion did not correlate with the presence or severity of tremor. Involvement of the anterior lobe and lobule VI was related to high tremor intensity. In all followed up patients with acute cerebellar ischemia, the tremor completely recovered within 8 weeks. Our results indicate that cerebellar lesions might induce pathological postural and intentional tremor of 2-3 Hz frequency. Due to its low frequency and low amplitude, quantitative tremorometry is neccessary to properly identify it. There is no tight correlation between lesion localization and quantitative characteristics of cerebellar tremor.
dc.format.extent 705-720
dc.title Characteristics of Tremor Induced by Lesions of the Cerebellum
dc.type Journal Article
dc.date.updated 2019-10-26T16:30:18Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30780009
dc.identifier.wos 000476555900004
dc.identifier.pubmed 30963396
dc.contributor.department SE/Rácz Károly Doktori Iskola
dc.contributor.department SE/AOK/K/Neurológiai Klinika
dc.contributor.institution Semmelweis Egyetem


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