dc.contributor.author |
Balogh, Mihály |
|
dc.contributor.author |
Varga, Bence Kálmán |
|
dc.contributor.author |
Karádi, Dávid Árpád |
|
dc.contributor.author |
Riba, Pál |
|
dc.contributor.author |
Puskár, Zita |
|
dc.contributor.author |
Kozsurek, Márk |
|
dc.contributor.author |
Al-Khrasani, Mahmoud |
|
dc.contributor.author |
Király, Kornél |
|
dc.date.accessioned |
2022-06-20T10:07:22Z |
|
dc.date.available |
2022-06-20T10:07:22Z |
|
dc.date.issued |
2019 |
|
dc.identifier |
85061832456 |
|
dc.identifier.citation |
journalVolume=147;journalTitle=BRAIN RESEARCH BULLETIN;pagerange=78-85;journalAbbreviatedTitle=BRAIN RES BULL; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7971 |
|
dc.identifier.uri |
doi:10.1016/j.brainresbull.2019.02.001 |
|
dc.description.abstract |
Dipeptidyl-peptidase 4 (DPP4) enzyme is involved in the degradation of many biologically active peptides including opioids. Its role in pain transmission is poorly elucidated. Recently we reported on the spinal antihyperalgesic effects of DPP4 inhibitors, Ile-Pro-Ile (Diprotin A) and vildagliptin in carrageenan-evoked acute inflammatory pain in rats. The present study investigated the effects of intrathecal (it.) diprotin A and vildagliptin in Complete Freund's Adjuvant- (CFA) and formalin induced pain in rats. The former assay can model the subchronic inflammatory pain condition and the later one reflects both acute tonic and inflammatory pain conditions. The involvement of opioid receptor (OR) subtypes, Y1-, and GLP1 receptors were also investigated. In CFA pain model it. diprotin A or vildagliptin dose-dependently inhibits hyperalgesia in ipsilateral while has no effect in contralateral paws. The peak effect was achieved 30 min following drug administration which was used for further analysis. Both compounds showed naltrexone reversible antihyperalgesia. Co-administration of OR-subtype-selective antagonists with diprotin A and vildagliptin revealed involvement of μ and δ > μ opioid receptors, respectively. Co-administered Y1 but not GLP1 receptor antagonists reversed the antihyperalgesic action of both DPP4 inhibitors. In touch-hypersensitivity both compounds were ineffective. In formalin test only diprotin A showed μ and δ OR-mediated antinociception and only in the 2nd phase. This effect was Y1 or GLP-1 receptor antagonist insensitive. In conclusion, diprotin A and vildagliptin display antinociception of different mechanisms of action in subchronic inflammatory pain. Furthermore, the spinal pain relay points of inflammatory pain of acute or subchronic conditions were more effectively affected by diprotin A than vildagliptin which needs future elucidation. |
|
dc.format.extent |
78-85 |
|
dc.relation.ispartof |
urn:issn:0361-9230 |
|
dc.title |
Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-11-20T14:15:28Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30459956 |
|
dc.identifier.wos |
000462802100008 |
|
dc.identifier.pubmed |
30738866 |
|
dc.contributor.institution |
Anatómiai, Szövet- és Fejlődéstani Intézet |
|
dc.contributor.institution |
Anatómiai, Szövet- és Fejlődéstani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.contributor.institution |
Farmakológiai és Farmakoterápiás Intézet |
|
dc.contributor.institution |
MTA-SE Neuropszichofarmakológiai Kutatócsoport (2007-től társult tag) |
|
dc.contributor.institution |
Rácz Károly Doktori Iskola |
|
dc.mtmt.swordnote |
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, Budapest, H-1445, Hungary
Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Tűzoltó u. 58, P.O.Box 2, Budapest, H-1428, Hungary
Export Date: 13 September 2019
CODEN: BRBUD
Correspondence Address: Király, K.; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, Hungary; email: kiraly.kornel@med.semmelweis-univ.hu |
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