Show simple item record Lázár, Bernadette Brenner, Gábor Makkos, András Balogh, Mihály László, Szilvia Bianka Al-Khrasani, Mahmoud Hutka, Barbara Bató, Emese Ostorházi, Eszter Juhász, János Kemény, Ágnes Horváthné László, Terézia Tiszlavicz, László Bihari, Zoltán Giricz, Zoltán Szabó, Dóra Helyes, Zsuzsanna Ferdinandy, Péter Gyires, Klára Zádori, Zoltán S 2020-05-08T09:49:05Z 2020-05-08T09:49:05Z 2019
dc.identifier.citation journalVolume=8;journalIssueNumber=3;pagination=251, pages: 17;journalTitle=CELLS;journalAbbreviatedTitle=CELLS;
dc.identifier.uri doi:10.3390/cells8030251
dc.description.abstract Intestinal dysbiosis is linked to numerous gastrointestinal disorders, including inflammatory bowel diseases. It is a question of debate if coxibs, selective inhibitors of cyclooxygenase (COX)-2, cause dysbiosis. Therefore, in the present study, we aimed to determine the effect of long-term (four weeks) selective inhibition of COX-2 on the small intestinal microbiota in the rat. In order to avoid mucosal damage due to topical effects and inflammation-driven microbial alterations, rofecoxib, a nonacidic compound, was used. The direct inhibitory effect of rofecoxib on the growth of bacteria was ruled out in vitro. The mucosa-sparing effect of rofecoxib was confirmed by macroscopic and histological analysis, as well as by measuring the intestinal levels of cytokines and tight junction proteins. Deep sequencing of bacterial 16S rRNA revealed that chronic rofecoxib treatment had no significant influence on the composition and diversity of jejunal microbiota. In conclusion, this is the first demonstration that long-term selective inhibition of COX-2 by rofecoxib does not cause small intestinal dysbiosis in rats. Moreover, inhibition of COX-2 activity is not likely to be responsible per se for microbial alterations caused by some coxibs, but other drug-specific properties may contribute to it.
dc.relation.ispartof urn:issn:2073-4409
dc.title Lack of Small Intestinal Dysbiosis Following Long-Term Selective Inhibition of Cyclooxygenase-2 by Rofecoxib in the Rat
dc.type Journal Article 2019-11-20T14:23:31Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30605196
dc.identifier.wos 000464200900001
dc.identifier.pubmed 30884758
dc.contributor.department SE/AOK/I/Farmakológiai és Farmakoterápiás Intézet
dc.contributor.department SE/AOK/I/Orvosi Mikrobiológiai Intézet
dc.contributor.institution Semmelweis Egyetem

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