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dc.contributor.author Cherfils-Vicini, Julien
dc.contributor.author Iltis, Charlene
dc.contributor.author Cervera, Ludovic
dc.contributor.author Pisano, Sabrina
dc.contributor.author Croce, Olivier
dc.contributor.author Sadouni, Nori
dc.contributor.author Győrffy, Balázs
dc.contributor.author Collet, Romy
dc.contributor.author Renault, Valérie M
dc.contributor.author Rey-Millet, Martin
dc.contributor.author Leonetti, Carlo
dc.contributor.author Zizza, Pasquale
dc.contributor.author Allain, Fabrice
dc.contributor.author Ghiringhelli, Francois
dc.contributor.author Soubeiran, Nicolas
dc.contributor.author Shkreli, Marina
dc.contributor.author Vivier, Eric
dc.contributor.author Biroccio, Annamaria
dc.contributor.author Gilson, Eric
dc.date.accessioned 2020-04-15T11:49:57Z
dc.date.available 2020-04-15T11:49:57Z
dc.date.issued 2019
dc.identifier 85064630802
dc.identifier.citation journalVolume=38;journalIssueNumber=11;pagination=e100012, pages: 20;journalTitle=EMBO JOURNAL;journalAbbreviatedTitle=EMBO J;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/8015
dc.identifier.uri doi:10.15252/embj.2018100012
dc.description.abstract Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with strong immunosuppressive activity that promote tumor growth. In this study, we describe a mechanism by which cancer cells control MDSCs in human cancers by upregulating TRF2, a protein required for telomere stability. Specifically, we showed that the TRF2 upregulation in cancer cells has extratelomeric roles in activating the expression of a network of genes involved in the biosynthesis of heparan sulfate proteoglycan, leading to profound changes in glycocalyx length and stiffness, as revealed by atomic force microscopy. This TRF2-dependent regulation facilitated the recruitment of MDSCs, their activation via the TLR2/MyD88/IL-6/STAT3 pathway leading to the inhibition of natural killer recruitment and cytotoxicity, and ultimately tumor progression and metastasis. The clinical relevance of these findings is supported by our analysis of cancer cohorts, which showed a correlation between high TRF2 expression and MDSC infiltration, which was inversely correlated with overall patient survival.
dc.relation.ispartof
dc.title Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2
dc.type Journal Article
dc.date.updated 2019-11-26T14:54:53Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 30650205
dc.identifier.wos 000470014200009
dc.identifier.pubmed 31000523
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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