dc.contributor.author |
Schölch, Sebastian |
|
dc.contributor.author |
Bogner, Andreas |
|
dc.contributor.author |
Bork, Ulrich |
|
dc.contributor.author |
Rahbari, Mohammad |
|
dc.contributor.author |
Győrffy, Balázs |
|
dc.contributor.author |
Schneider, Martin |
|
dc.contributor.author |
Reissfelder, Christoph |
|
dc.contributor.author |
Weitz, Jürgen |
|
dc.contributor.author |
Rahbari, Nuh N |
|
dc.date.accessioned |
2019-12-04T12:28:15Z |
|
dc.date.available |
2019-12-04T12:28:15Z |
|
dc.date.issued |
2019 |
|
dc.identifier |
85069946855 |
|
dc.identifier.citation |
journalVolume=9;journalIssueNumber=1;pagination=10921, pages: 12;journalTitle=SCIENTIFIC REPORTS;journalAbbreviatedTitle=SCI REP; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/8025 |
|
dc.identifier.uri |
doi:10.1038/s41598-019-47429-5 |
|
dc.description.abstract |
The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p = 0.029; VC: HR 1.091; p = 0.009). Conversely, elevated EGF is associated with favorable DFS (TC: HR 0.998; p = 0.045; VC: HR 0.998; p = 0.018) but not OS (TC: p = 0.201; VC: p = 0.453). None of the other angiogenic cytokines correlated with prognosis. The prognostic value of PlGF (OS + DFS) and EGF (DFS) was confirmed in both independent retrospective cohorts. Serum PlGF and EGF may serve as prognostic markers in non-metastatic CRC. |
|
dc.relation.ispartof |
urn:issn:2045-2322 |
|
dc.title |
Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-11-27T14:30:52Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30757812 |
|
dc.identifier.wos |
000477701800024 |
|
dc.identifier.pubmed |
31358848 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|