dc.contributor.author |
Paris, Kenneth |
|
dc.contributor.author |
Haddad, Elie |
|
dc.contributor.author |
Borte, Michael |
|
dc.contributor.author |
Brodszki, Nicholas |
|
dc.contributor.author |
Dérfalvi, Beáta |
|
dc.contributor.author |
Marodi, Laszlo |
|
dc.contributor.author |
Hussain, Iftikhar |
|
dc.contributor.author |
Darter, Amy |
|
dc.contributor.author |
Engl, Werner |
|
dc.contributor.author |
Leibl, Heinz |
|
dc.contributor.author |
McCoy, Barbara |
|
dc.contributor.author |
Yel, Leman |
|
dc.date.accessioned |
2020-03-04T14:35:40Z |
|
dc.date.available |
2020-03-04T14:35:40Z |
|
dc.date.issued |
2019 |
|
dc.identifier.citation |
journalVolume=11;journalIssueNumber=5;journalTitle=IMMUNOTHERAPY;pagerange=397-406;journalAbbreviatedTitle=IMMUNOTHERAPY-UK; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/8110 |
|
dc.identifier.uri |
doi:10.2217/imt-2018-0088 |
|
dc.description.abstract |
Aim: To assess Ig20Gly tolerability in pediatric patients with primary immunodeficiencies. Patients & methods: Infusion parameters and tolerability were analyzed in pediatric patients (aged 2-5 years [n=6], 6-11 years [n=22] and 12-17 years [n=22]) receiving Ig20Gly in two Phase II/III trials. Results: Of 2624 Ig20Gly infusions, >99% did not require any rate reduction, interruption or discontinuation due to adverse events (AEs). Median maximum infusion rates and volumes/site were higher in patients 12-17 years of age (30ml/h/site; 30ml/site) versus 6-11 years (20ml/h/site; 15ml/site) and 2-5 years (18ml/h/site; 14ml/site). Rates of causally related systemic and local AEs (0.009 and 0.063 AEs/infusion) were low. Conclusion: Ig20Gly infused at relatively high rates and volumes was well tolerated in children. |
|
dc.format.extent |
397-406 |
|
dc.relation.ispartof |
urn:issn:1750-743X |
|
dc.title |
Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies |
|
dc.type |
Journal Article |
|
dc.date.updated |
2020-01-08T17:21:11Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30590215 |
|
dc.identifier.wos |
000459478300002 |
|
dc.identifier.pubmed |
30626238 |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|