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dc.contributor.author Molnar, Maria Judit
dc.contributor.author Jimoh, Idris János
dc.contributor.author Zeke, Helga
dc.contributor.author Palásti, Ágnes
dc.contributor.author Fedor, Marianna
dc.date.accessioned 2020-04-28T09:06:46Z
dc.date.available 2020-04-28T09:06:46Z
dc.date.issued 2020
dc.identifier.citation journalVolume=11; pagination=477; journalTitle=FRONTIERS IN PHARMACOLOGY;journalAbbreviatedTitle=FRONT PHARMAC;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/8257
dc.identifier.uri doi:10.3389/fphar.2020.00477
dc.description.abstract Schizophrenia is a chronic and severe mental disorder characterized by positive, negative, and cognitive symptoms. Negative symptoms are usually present from the prodromal phase; early diagnosis and management of negative symptoms is a major health concern since an insidious onset dominated by negative symptoms is associated with a worse outcome. Antipsychotic medications, which are effective for treating positive symptoms, are generally ineffective for treating negative or cognitive symptoms. We present a 23-year-old woman showing severe symptoms at her first visit to our department. The patient’s parents reported that their daughter had experienced several years of psychosocial decline and putative psychiatric symptoms, but no medical attention had been previously sought; as such, the diagnosis of schizophrenia with predominantly negative symptoms was very much delayed. Early onset of schizophrenia, longer duration of untreated psychosis, and severe negative symptoms, which have limited treatment options, suggested a poor prognosis. We initiated monotherapy with cariprazine, a novel antipsychotic that has recently been proven efficacious in treating schizophrenia with predominantly negative symptoms. This report describes a 52-week cariprazine treatment regimen and follows the patient’s impressive clinical improvement confirmed by PANSS and CGI scores, and psychological tests.
dc.title Early-Onset Schizophrenia With Predominantly Negative Symptoms: A Case Study of a Drug-Naive Female Patient Treated With Cariprazine
dc.type Journal Article
dc.date.updated 2020-04-28T09:05:12Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 31293409
dc.contributor.institution Neurológiai Klinika
dc.contributor.institution Genomikai Medicina és Ritka Betegségek Intézete


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