Neutrophils as emerging therapeutic targets

dc.contributor.author	Németh, Tamás
dc.contributor.author	Sperandio, M.
dc.contributor.author	Mócsai, Attila
dc.date.accessioned	2020-09-21T08:25:50Z
dc.date.available	2020-09-21T08:25:50Z
dc.date.issued	2020
dc.identifier	85078096069
dc.identifier.citation	journalVolume=19;journalIssueNumber=4;journalTitle=NATURE REVIEWS DRUG DISCOVERY;pagerange=253-275;journalAbbreviatedTitle=NAT REV DRUG DISCOV;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/8278
dc.identifier.uri	doi:10.1038/s41573-019-0054-z
dc.description.abstract	Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate but complex involvement of neutrophils in various diseases makes them exciting targets for therapeutic intervention but also necessitates differentiation of beneficial responses from potentially detrimental side effects. A variety of approaches to therapeutically target neutrophils have emerged, including strategies to enhance, inhibit or restore neutrophil function, with several agents entering clinical trials. However, challenges and controversies in the field remain. © 2020, Springer Nature Limited.
dc.format.extent	253-275
dc.relation.ispartof	urn:issn:1474-1776
dc.title	Neutrophils as emerging therapeutic targets
dc.type	Journal Article
dc.date.updated	2020-05-12T08:32:07Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	31156872
dc.identifier.wos	000508796200001
dc.identifier.scopus	85078096069
dc.identifier.pubmed	31969717
dc.contributor.department	SE/AOK/I/Élettani Intézet
dc.contributor.institution	Semmelweis Egyetem
dc.mtmt.swordnote	Export Date: 4 February 2020 CODEN: NRDDA Correspondence Address: Németh, T.; Department of Physiology, Semmelweis University School of MedicineHungary; email: nemeth.tamas@med.semmelweis-univ.hu Funding details: 777357 Funding details: VEKOP-2.3.2-16-2016-00002, K-NVKP_16-1-2016-0152956, KKP 129954 Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB 914 Funding text 1: The authors apologize to the authors of numerous outstanding publications that had to be omitted due to space limitations. This work was supported by the Hungarian National Agency for Research, Development and Innovation (K-NVKP_16-1-2016-0152956, VEKOP-2.3.2-16-2016-00002 and KKP 129954 to A.M.), the European Union’s Horizon 2020 IMI2 programme (RTCure project; grant no. 777357 to A.M.) and the Deutsche Forschungsgemeinschaft (SFB 914 projects B01 and Z03, grant no. SP621/5-1 to M.S.). Export Date: 5 February 2020 CODEN: NRDDA Correspondence Address: Németh, T.; Department of Physiology, Semmelweis University School of MedicineHungary; email: nemeth.tamas@med.semmelweis-univ.hu Funding details: 777357 Funding details: VEKOP-2.3.2-16-2016-00002, K-NVKP_16-1-2016-0152956, KKP 129954 Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB 914 Funding text 1: The authors apologize to the authors of numerous outstanding publications that had to be omitted due to space limitations. This work was supported by the Hungarian National Agency for Research, Development and Innovation (K-NVKP_16-1-2016-0152956, VEKOP-2.3.2-16-2016-00002 and KKP 129954 to A.M.), the European Union’s Horizon 2020 IMI2 programme (RTCure project; grant no. 777357 to A.M.) and the Deutsche Forschungsgemeinschaft (SFB 914 projects B01 and Z03, grant no. SP621/5-1 to M.S.). Export Date: 10 February 2020 CODEN: NRDDA Correspondence Address: Németh, T.; Department of Physiology, Semmelweis University School of MedicineHungary; email: nemeth.tamas@med.semmelweis-univ.hu Funding details: 777357 Funding details: VEKOP-2.3.2-16-2016-00002, K-NVKP_16-1-2016-0152956, KKP 129954 Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB 914 Funding text 1: The authors apologize to the authors of numerous outstanding publications that had to be omitted due to space limitations. This work was supported by the Hungarian National Agency for Research, Development and Innovation (K-NVKP_16-1-2016-0152956, VEKOP-2.3.2-16-2016-00002 and KKP 129954 to A.M.), the European Union’s Horizon 2020 IMI2 programme (RTCure project; grant no. 777357 to A.M.) and the Deutsche Forschungsgemeinschaft (SFB 914 projects B01 and Z03, grant no. SP621/5-1 to M.S.).