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dc.contributor.author Giancane, Gabriella
dc.contributor.author Swart, Joost F
dc.contributor.author Castagnola, Elio
dc.contributor.author Groll, Andreas H
dc.contributor.author Horneff, Gerd
dc.contributor.author Huppertz, Hans-Iko
dc.contributor.author Lovell, Daniel J
dc.contributor.author Wolfs, Tom
dc.contributor.author Herlin, Troels
dc.contributor.author Dolezalova, Pavla
dc.contributor.author Sanner, Helga
dc.contributor.author Susic, Gordana
dc.contributor.author Sztajnbok, Flavio
dc.contributor.author Maritsi, Despoina
dc.contributor.author Constantin, Tamás
dc.contributor.author Vargova, Veronika
dc.contributor.author Sawhney, Sujata
dc.contributor.author Rygg, Marite
dc.contributor.author K Oliveira, Sheila
dc.contributor.author Cattalini, Marco
dc.contributor.author Bovis, Francesca
dc.contributor.author Bagnasco, Francesca
dc.contributor.author Pistorio, Angela
dc.contributor.author Martini, Alberto
dc.contributor.author Wulffraat, Nico
dc.contributor.author Ruperto, Nicolino
dc.contributor.author Cuttica, Ruben
dc.contributor.author Garay, Stella Maris
dc.contributor.author Brunner, Jurgen
dc.contributor.author Emminger, Wolfgang
dc.contributor.author Appenzeller, Simone
dc.contributor.author Len, Claudio
dc.contributor.author Saad Magalhaes, Claudia
dc.contributor.author Telcharova-Mihaylovska, Albena
dc.contributor.author Harjacek, Miroslav
dc.contributor.author Jelusic, Marija
dc.contributor.author Estmann, Anne
dc.contributor.author Nielsen, Susan
dc.contributor.author Herrera Mora, Cristina
dc.contributor.author Gervais, Elisabeth
dc.contributor.author Koné-Paut, Isabelle
dc.contributor.author Quartier, Pierre
dc.contributor.author Foeldvari, Ivan
dc.contributor.author Horneff, Gerd
dc.contributor.author Lutz, Thomas
dc.contributor.author Minden, Kirsten
dc.contributor.author Tzaribachev, Nikolay
dc.contributor.author Trachana, Maria
dc.contributor.author Tsitsami, Elena
dc.contributor.author Vougiouka, Olga
dc.contributor.author Orban, Ilonka
dc.contributor.author Harel, Liora
dc.contributor.author Hashkes, Philip
dc.contributor.author Uziel, Yosef
dc.contributor.author Cimaz, Rolando
dc.contributor.author Civino, Adele
dc.contributor.author Consolini, Rita
dc.contributor.author D'Angelo, Gianfranco
dc.contributor.author De Benedetti, Fabrizio
dc.contributor.author Filocamo, Giovanni
dc.contributor.author Fueri, Elena
dc.contributor.author Gallizzi, Romina
dc.contributor.author Maggio, Maria Cristina
dc.contributor.author Magnolia, Maria Greca
dc.contributor.author Miniaci, Angela
dc.contributor.author Montin, Davide
dc.contributor.author Olivieri, Alma Nunzia
dc.contributor.author Pastore, Serena
dc.contributor.author Rigante, Donato
dc.contributor.author Zulian, Francesco
dc.contributor.author Rumba-Rozenfelde, Ingrida
dc.contributor.author Stanevicha, Valda
dc.contributor.author Panaviene, Violeta
dc.contributor.author Rodriguez Lozano, Ana Luisa
dc.contributor.author Rubio-Perez, Nadina
dc.contributor.author Vega Cornejo, Gabriel
dc.contributor.author Hoppenreijs, Esther
dc.contributor.author Kamphuis, Sylvia
dc.contributor.author Flato, Berit
dc.contributor.author Nordal, Ellen Berit
dc.contributor.author Abdwani, Reem
dc.contributor.author Miraval, Tatiana
dc.contributor.author Paz Gastanaga, Maria Eliana
dc.contributor.author Smolewska, Elzbieta
dc.contributor.author Ailioaie, Constantin
dc.contributor.author Cochino, Alexis-Virgil
dc.contributor.author Laday, Matilda
dc.contributor.author Lazar, Calin
dc.contributor.author Alexeeva, Ekaterina
dc.contributor.author Chasnyk, Vyacheslav
dc.contributor.author Keltsev, Vladimir
dc.contributor.author Suwairi, Wafaa Mohammed Saad
dc.contributor.author Vijatov-Djuric, Gordana
dc.contributor.author Vojinovic, Jelena
dc.contributor.author Arkachaisri, Thaschawee
dc.contributor.author Koskova, Elena
dc.contributor.author Avcin, Tadej
dc.contributor.author Ally, Mahmood
dc.contributor.author Van Rensburg, Christa Janse
dc.contributor.author Louw, Ingrid
dc.contributor.author Lopez, Jordi Anton
dc.contributor.author Boteanu, Alina Lucica
dc.contributor.author Calvo Penades, Inmaculada
dc.contributor.author De Inocencio, Jaime
dc.contributor.author Mesa-Del-Castillo, Pablo
dc.contributor.author Moreno, Estefania
dc.contributor.author Remesal, Agustin
dc.contributor.author Hofer, Michael
dc.contributor.author Gok, Faysal
dc.contributor.author Ozen, Seza
dc.contributor.author Ramanan, Athimalaipet
dc.contributor.author Pallotti, Chiara
dc.contributor.author Villa, Luca
dc.date.accessioned 2020-09-14T07:05:09Z
dc.date.available 2020-09-14T07:05:09Z
dc.date.issued 2020
dc.identifier.citation journalVolume=22;journalIssueNumber=1;journalTitle=ARTHRITIS RESEARCH & THERAPY;;pagination=71, pages: 15;journalAbbreviatedTitle=ARTHRITIS RES THER;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/8292
dc.identifier.uri doi:10.1186/s13075-020-02167-2
dc.description.abstract To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI.A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI.We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies.Clinicaltrials.gov NCT01399281; ENCePP seal: awarded on 25 November 2011.
dc.relation.ispartof urn:issn:1478-6354
dc.title Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis
dc.type Journal Article
dc.date.updated 2020-05-22T07:37:02Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 31320601
dc.identifier.wos 000526738400002
dc.identifier.pubmed 32264969
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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