Show simple item record Giancane, Gabriella Swart, Joost F Castagnola, Elio Groll, Andreas H Horneff, Gerd Huppertz, Hans-Iko Lovell, Daniel J Wolfs, Tom Herlin, Troels Dolezalova, Pavla Sanner, Helga Susic, Gordana Sztajnbok, Flavio Maritsi, Despoina Constantin, Tamás Vargova, Veronika Sawhney, Sujata Rygg, Marite K Oliveira, Sheila Cattalini, Marco Bovis, Francesca Bagnasco, Francesca Pistorio, Angela Martini, Alberto Wulffraat, Nico Ruperto, Nicolino Cuttica, Ruben Garay, Stella Maris Brunner, Jurgen Emminger, Wolfgang Appenzeller, Simone Len, Claudio Saad Magalhaes, Claudia Telcharova-Mihaylovska, Albena Harjacek, Miroslav Jelusic, Marija Estmann, Anne Nielsen, Susan Herrera Mora, Cristina Gervais, Elisabeth Koné-Paut, Isabelle Quartier, Pierre Foeldvari, Ivan Horneff, Gerd Lutz, Thomas Minden, Kirsten Tzaribachev, Nikolay Trachana, Maria Tsitsami, Elena Vougiouka, Olga Orban, Ilonka Harel, Liora Hashkes, Philip Uziel, Yosef Cimaz, Rolando Civino, Adele Consolini, Rita D'Angelo, Gianfranco De Benedetti, Fabrizio Filocamo, Giovanni Fueri, Elena Gallizzi, Romina Maggio, Maria Cristina Magnolia, Maria Greca Miniaci, Angela Montin, Davide Olivieri, Alma Nunzia Pastore, Serena Rigante, Donato Zulian, Francesco Rumba-Rozenfelde, Ingrida Stanevicha, Valda Panaviene, Violeta Rodriguez Lozano, Ana Luisa Rubio-Perez, Nadina Vega Cornejo, Gabriel Hoppenreijs, Esther Kamphuis, Sylvia Flato, Berit Nordal, Ellen Berit Abdwani, Reem Miraval, Tatiana Paz Gastanaga, Maria Eliana Smolewska, Elzbieta Ailioaie, Constantin Cochino, Alexis-Virgil Laday, Matilda Lazar, Calin Alexeeva, Ekaterina Chasnyk, Vyacheslav Keltsev, Vladimir Suwairi, Wafaa Mohammed Saad Vijatov-Djuric, Gordana Vojinovic, Jelena Arkachaisri, Thaschawee Koskova, Elena Avcin, Tadej Ally, Mahmood Van Rensburg, Christa Janse Louw, Ingrid Lopez, Jordi Anton Boteanu, Alina Lucica Calvo Penades, Inmaculada De Inocencio, Jaime Mesa-Del-Castillo, Pablo Moreno, Estefania Remesal, Agustin Hofer, Michael Gok, Faysal Ozen, Seza Ramanan, Athimalaipet Pallotti, Chiara Villa, Luca 2020-09-14T07:05:09Z 2020-09-14T07:05:09Z 2020
dc.identifier.citation journalVolume=22;journalIssueNumber=1;journalTitle=ARTHRITIS RESEARCH & THERAPY;;pagination=71, pages: 15;journalAbbreviatedTitle=ARTHRITIS RES THER;
dc.identifier.uri doi:10.1186/s13075-020-02167-2
dc.description.abstract To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI.A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI.We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance NCT01399281; ENCePP seal: awarded on 25 November 2011.
dc.relation.ispartof urn:issn:1478-6354
dc.title Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis
dc.type Journal Article 2020-05-22T07:37:02Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 31320601
dc.identifier.wos 000526738400002
dc.identifier.pubmed 32264969
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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