Kivonat:
Allelic distribution of -308 G>A (TNF 1/2) polymorphism of the TNF-alpha, and the
+252 A>G promoter polymorphism of the LT-alpha gene, the 1267 A>G polymorphism of
the HSP70-2 gene as well as the -429 T>C promoter polymorphism of the RAGE gene
were tested in 94 MM cases and 141 controls. Significantly less MM patients than
controls carried the TNF2 allele (p=0.018) and the TNF2-LTA 252G haplotype
(p=0.025). The difference was, however, restricted to the females, as well as the
relatively young (<69 years) subjects. By contrast, we did not find differences
with the other SNPs tested.