dc.contributor.author |
Czeizel Endre |
|
dc.contributor.author |
Dudas I |
|
dc.contributor.author |
Paput László |
|
dc.contributor.author |
Bánhidy Ferenc |
|
dc.date.accessioned |
2014-12-22T09:11:43Z |
|
dc.date.available |
2014-12-22T09:11:43Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
80051928219 |
|
dc.identifier.citation |
pagination=263-271;
journalVolume=58;
journalIssueNumber=4;
journalTitle=ANNALS OF NUTRITION AND METABOLISM; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/833 |
|
dc.identifier.uri |
doi:10.1159/000330776 |
|
dc.description.abstract |
Background/Aims: To review the main results of intervention trials which showed the efficacy of periconceptional folic acid-containing multivitamin and folic acid supplementation in the prevention of neural-tube defects (NTD). Methods and Results: The main findings of 5 intervention trials are known: (i) the efficacy of a multivitamin containing 0.36 mg folic acid in a UK nonrandomized controlled trial resulted in an 83-91% reduction in NTD recurrence, while the results of the Hungarian (ii) randomized controlled trial and (iii) cohort-controlled trial using a multivitamin containing 0.8 mg folic acid showed 93 and 89% reductions in the first occurrence of NTD, respectively. On the other hand, (iv) another multicenter randomized controlled trial proved a 71% efficacy of 4 mg folic acid in the reduction of recurrent NTD, while (v) a public health-oriented Chinese-US trial showed a 41-79% reduction in the first occurrence of NTD depending on the incidence of NTD. Conclusions: Translational application of these findings could result in a breakthrough in the primary prevention of NTD, but so far this is not widely applied in practice. The benefits and drawbacks of 4 main possible uses of periconceptional folic acid/multivitamin supplementation, i.e. (i) dietary intake, (ii) periconceptional supplementation, (iii) flour fortification, and (iv) the recent attempt for the use of combination of oral contraceptives with 6S-5-methytetrahydrofolate (methylfolate), are discussed. Obviously, prevention of NTD is much better than the frequent elective termination of pregnancies after prenatal diagnosis of NTD fetuses. |
|
dc.relation.ispartof |
urn:issn:0250-6807 |
|
dc.title |
Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins? |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-12-18T09:34:37Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1740297 |
|
dc.identifier.wos |
000296422500001 |
|
dc.identifier.pubmed |
21865678 |
|
dc.contributor.department |
SE/ÁOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|