Show simple item record Czeizel Endre Dudas I Paput László Bánhidy Ferenc 2014-12-22T09:11:43Z 2014-12-22T09:11:43Z 2011
dc.identifier 80051928219
dc.identifier.citation pagination=263-271; journalVolume=58; journalIssueNumber=4; journalTitle=ANNALS OF NUTRITION AND METABOLISM;
dc.identifier.uri doi:10.1159/000330776
dc.description.abstract Background/Aims: To review the main results of intervention trials which showed the efficacy of periconceptional folic acid-containing multivitamin and folic acid supplementation in the prevention of neural-tube defects (NTD). Methods and Results: The main findings of 5 intervention trials are known: (i) the efficacy of a multivitamin containing 0.36 mg folic acid in a UK nonrandomized controlled trial resulted in an 83-91% reduction in NTD recurrence, while the results of the Hungarian (ii) randomized controlled trial and (iii) cohort-controlled trial using a multivitamin containing 0.8 mg folic acid showed 93 and 89% reductions in the first occurrence of NTD, respectively. On the other hand, (iv) another multicenter randomized controlled trial proved a 71% efficacy of 4 mg folic acid in the reduction of recurrent NTD, while (v) a public health-oriented Chinese-US trial showed a 41-79% reduction in the first occurrence of NTD depending on the incidence of NTD. Conclusions: Translational application of these findings could result in a breakthrough in the primary prevention of NTD, but so far this is not widely applied in practice. The benefits and drawbacks of 4 main possible uses of periconceptional folic acid/multivitamin supplementation, i.e. (i) dietary intake, (ii) periconceptional supplementation, (iii) flour fortification, and (iv) the recent attempt for the use of combination of oral contraceptives with 6S-5-methytetrahydrofolate (methylfolate), are discussed. Obviously, prevention of NTD is much better than the frequent elective termination of pregnancies after prenatal diagnosis of NTD fetuses.
dc.relation.ispartof urn:issn:0250-6807
dc.title Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?
dc.type Journal Article 2014-12-18T09:34:37Z
dc.language.rfc3066 en
dc.identifier.mtmt 1740297
dc.identifier.wos 000296422500001
dc.identifier.pubmed 21865678
dc.contributor.department SE/ÁOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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