dc.contributor.author |
Kalász, Huba |
|
dc.contributor.author |
Szimrók, Zoltán |
|
dc.contributor.author |
Karvaly, Gellért Balázs |
|
dc.contributor.author |
Adeghate, Jennifer |
|
dc.contributor.author |
Tekes, Kornélia |
|
dc.date.accessioned |
2020-09-05T15:43:44Z |
|
dc.date.available |
2020-09-05T15:43:44Z |
|
dc.date.issued |
2020 |
|
dc.identifier |
85081647341 |
|
dc.identifier.citation |
journalVolume=25;journalIssueNumber=5;jpagination=Paper 1250, 9 pages; journalTitle=MOLECULES;journalAbbreviatedTitle=MOLECULES; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/8449 |
|
dc.identifier.uri |
doi:10.3390/molecules25051250 |
|
dc.description.abstract |
Our aim was to find chlorine-substituted antidotes against organophosphate poisoning and compare their pharmacokinetics to their parent compound, K-203. White male Wistar rats were intramuscularly injected with K-203, K-867 or K-870. Serum, brain, kidneys, liver, lung, eyes, and testes tissues were taken after 5, 15, 30, 60, and 120 min and analyzed using reversed-phase high-performance liquid chromatography. K-203, K-867, or K-870 was present in every tissue that was analyzed, including the serum, the eyes, testes, liver, kidneys, lungs, and the brain. The serum levels of K-867 and K-870 (chlorine-substituted derivatives of K-203) were nearly constant between 15 and 30 min, while their parent compound (K-203) showed peak level at 15 min after the administration of 30 µmol/rat. Neither K-203, nor K-867 or K-870 were toxic at a dose of 100 µmol/200 g in rats. Chlorine-substitution of K-867 and K-870 produced limited absorbance and distribution compared to their parent compound, K203. |
|
dc.title |
Pharmacokinetics of Two Chlorine-Substituted Bis-Pyridinium Mono-Aldoximes with Regenerating Effect on Butyrylcholinesterase |
|
dc.type |
Journal Article |
|
dc.date.updated |
2020-09-05T15:13:12Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
31250084 |
|
dc.identifier.wos |
000529219900233 |
|
dc.identifier.pubmed |
32164301 |
|
dc.contributor.department |
SE/AOK/I/Farmakológiai és Farmakoterápiás Intézet |
|
dc.contributor.department |
SE/GYTK/Gyógyszerhatástani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Export Date: 25 March 2020
CODEN: MOLEF
Correspondence Address: Kalász, H.; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, Hungary; email: drkalasz@gmail.com
Export Date: 19 April 2020
CODEN: MOLEF
Export Date: 13 July 2020
CODEN: MOLEF
Correspondence Address: Kalász, H.; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, Hungary; email: drkalasz@gmail.com |
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