dc.contributor.author |
Horváth, Péter |
|
dc.contributor.author |
Lázár, Zsófia |
|
dc.contributor.author |
Gálffy, Gabriella |
|
dc.contributor.author |
Puskás, Rita |
|
dc.contributor.author |
Kunos, László |
|
dc.contributor.author |
Losonczy, György |
|
dc.contributor.author |
Mészéros, Martina |
|
dc.contributor.author |
Tárnoki, Ádám Domonkos |
|
dc.contributor.author |
Tárnoki, Dávid László |
|
dc.contributor.author |
Bikov, András |
|
dc.date.accessioned |
2021-08-30T07:59:20Z |
|
dc.date.available |
2021-08-30T07:59:20Z |
|
dc.date.issued |
2020 |
|
dc.identifier |
85077526804 |
|
dc.identifier.citation |
journalVolume=198;journalIssueNumber=1;journalTitle=LUNG;pagerange=173-179;journalAbbreviatedTitle=LUNG; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/8489 |
|
dc.identifier.uri |
doi:10.1007/s00408-019-00299-0 |
|
dc.description.abstract |
Purpose Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea. Methods Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea-hypopnea index >= 5/h. Results PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8-40.8 ng/ml) and patients with OSA (19.6/8.4-56.8, p = 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4-56.8 ng/ml) compared to mild OSA patients (14.1/8.5-35.3 ng/ml, p = 0.006) and controls (p = 0.03). Conclusions P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA. |
|
dc.format.extent |
173-179 |
|
dc.relation.ispartof |
urn:issn:0341-2040 |
|
dc.title |
Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients |
|
dc.type |
Journal Article |
|
dc.date.updated |
2020-09-22T20:08:18Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
31106599 |
|
dc.identifier.wos |
000505357600001 |
|
dc.identifier.pubmed |
31897593 |
|
dc.contributor.department |
SE/AOK/K/Pulmonológiai Klinika |
|
dc.contributor.department |
SE/AOK/K/Orvosi Képalkotó Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|