Kivonat:
Periodic limb movements in sleep (PLMS) is prevalent among
dialysed patients and is associated with increased risk of
mortality. Our study aimed to determine the prevalence of this
disease in a sample of transplanted and waiting-list
haemodialysed patients. One hundred transplanted and 50 waiting-
list patients underwent polysomnography. Moderate and severe
diseases were defined as periodic limb movements in sleep index
(PLMSI) higher than 15 and 25 events h(-1) , respectively. The
10-year coronary heart disease risk was estimated for all
patients using the Framingham Score. Moreover, the 10-year
estimated risk of stroke was calculated according to the
modified version of the Framingham Stroke Risk Profile. PLMS
was present in 27% of the transplanted and 42% of the waiting-
list group (P = 0.094); the proportion of severe disease was
twice as high in waiting-list versus transplanted patients (32
versus 16%, P = 0.024). Patients with severe disease had a
higher 10-year estimated risk of stroke in the transplanted
group [10 (7-17) versus 5 (4-10); P = 0.002] and a higher 10-
year coronary heart disease risk in both the transplanted [18
(8-22) versus 7 (4-14); P = 0.002], and the waiting-list groups
[11 (5-18) versus 4 (1-9); P = 0.032]. In multivariable linear
regression models the PLMSI was associated independently with
the Framingham cardiovascular and cerebrovascular scores after
adjusting for important covariables. Higher PLMSI is an
independent predictor of higher cardiovascular and
cerebrovascular risk score in patients with chronic kidney
disease. Severe PLMS is less frequent in kidney transplant
recipients compared to waiting-list dialysis patients.