dc.contributor.author |
Telkes Gábor |
|
dc.contributor.author |
Péter Antal |
|
dc.contributor.author |
Tulassay Zsolt |
|
dc.contributor.author |
Asderakis A |
|
dc.date.accessioned |
2015-01-05T10:52:12Z |
|
dc.date.available |
2015-01-05T10:52:12Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
79551505293 |
|
dc.identifier.citation |
pagination=727-732;
journalVolume=26;
journalIssueNumber=2;
journalTitle=NEPHROLOGY DIALYSIS TRANSPLANTATION; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/875 |
|
dc.identifier.uri |
doi:10.1093/ndt/gfq401 |
|
dc.description.abstract |
BACKGROUND: Although gastrointestinal (GI) symptoms are very frequent in organ transplant patients, there is a paucity of data about the endoscopic findings of kidney recipients. METHODS: Two thousand one hundred and thirty-five kidney transplants were performed between 1994 and 2007. During that period, 672 gastroscopies were performed in 543 of those patients. Their mean age was 49.5 years and 56.9% were male. Immunosuppressive combinations included cyclosporine-mycophenolate-steroids, cyclosporine-steroids and tacrolimus-mycophenolate mofetil-steroids. Ninety-eight percent of the patients received acid suppression therapy. RESULTS: The rate of clinically significant endoscopic findings was 84%. Macroscopic findings included inflammation in 46.7%, oesophagitis in 24.7%, ulcer in 16.9% and erosions in 14.8% of cases. Twenty-nine percent of endoscopies showed ulcer disease more frequently in the first 3 months (P=0.0014) after transplantation than later, and 45.7% of all ulcers developed in the first year. The presence of Helicobacter pylori was verified in 20.9% of cases, less than in the general, and also in the uraemic population (P<0.0001). There was no association between the presence of H. pylori and ulcers (P=0.28). Steroid pulse treatment for rejection was not associated with more ulcers (P=0.11); the use of mycophenolate mofetil increased the risk of erosions by 1.8-fold. CONCLUSION: More than 25% of all kidney recipients required upper endoscopy in their 'post-transplant life'; the prevalence of 'positive findings' and ulcer disease was higher than in the general population (P<0.0001). The most vulnerable period is the first 3 months. Mycophenolate mofetil had an impact on GI complications, whilst the presence of H. pylori in the transplant population is not associated with the presence of ulcers. |
|
dc.relation.ispartof |
urn:issn:0931-0509 |
|
dc.title |
High frequency of ulcers, not associated with Helicobacter pylori, in the stomach in the first year after kidney transplantation |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-12-22T10:31:09Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1870704 |
|
dc.identifier.pubmed |
20603242 |
|
dc.contributor.department |
SE/ÁOK/K/II. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/ÁOK/K/IISZBK/MTA-SE Molekuláris Medicina Kutatócsoport (2006-ig: MTA-SE Gastroenterológiai és Endocrinológiai Kutatócsoport) |
|
dc.contributor.department |
SE/ÁOK/K/Transzplantációs és Sebészeti Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|