Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis

dc.contributor.author	Rausz Eszter Zsófia
dc.contributor.author	Szilágyi Ágnes
dc.contributor.author	Nedoszytko B
dc.contributor.author	Lange M
dc.contributor.author	Niedoszytko M
dc.contributor.author	Lautner-Csorba Orsolya
dc.contributor.author	Falus András
dc.contributor.author	Aladzsity István
dc.contributor.author	Kokai Márta
dc.contributor.author	Valent P
dc.contributor.author	Marschalkó Márta
dc.contributor.author	Hidvégi Bernadett
dc.contributor.author	Szakonyi József
dc.contributor.author	Csomor Judit
dc.contributor.author	Várkonyi Judit
dc.date.accessioned	2015-01-07T16:16:53Z
dc.date.available	2015-01-07T16:16:53Z
dc.date.issued	2013
dc.identifier	84872265226
dc.identifier.citation	pagination=216-219; journalVolume=160; journalIssueNumber=2; journalTitle=BRITISH JOURNAL OF HAEMATOLOGY;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/920
dc.identifier.uri	doi:10.1111/bjh.12086
dc.description.abstract	Mastocytosis is a rare disease with reported high interleukin-6 (IL6) levels influencing disease severity. The present study investigated polymorphisms within the genes that encode IL6 and its receptor (IL6R) in relation to mastocytosis development in a case-control design. Analysis of the IL6R Asp358Ala polymorphism showed that carriers of the AA genotype had a 2.5-fold lower risk for mastocytosis than those with the AC or CC genotypes. No association with mastocytosis was found for the IL6-174G/C polymorphism, however, it may influence the effect of IL6R polymorphism. To the best of our knowledge this is the first study analysing IL6/IL6R polymorphisms in mastocytosis.
dc.relation.ispartof	urn:issn:0007-1048
dc.title	Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis
dc.type	Journal Article
dc.date.updated	2015-01-06T13:22:23Z
dc.language.rfc3066	en
dc.identifier.mtmt	2159903
dc.identifier.wos	000313520300012
dc.identifier.pubmed	23078005
dc.contributor.department	SE/ÁOK/K/III. Sz. Belgyógyászati Klinika
dc.contributor.department	SE/ÁOK/K/Bőr-, Nemikórtani és Bőronkológiai Klinika
dc.contributor.department	SE/ÁOK/I/Genetikai, Sejt- és Immunbiológiai Intézet
dc.contributor.department	SE/ÁOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.institution	Semmelweis Egyetem
dc.mtmt.swordnote	Eszter Rausz and Agnes Szilagyi contributed equally to the study.