Show simple item record Mazák, Károly Noszál, Béla 2023-05-26T09:44:10Z 2023-05-26T09:44:10Z 2012
dc.identifier 84864914295
dc.identifier.citation journalVolume=55;journalIssueNumber=15;journalTitle=JOURNAL OF MEDICINAL CHEMISTRY;pagerange=6942-6947;journalAbbreviatedTitle=J MED CHEM;
dc.identifier.uri doi:
dc.description.abstract The complete set of species-specific partition coefficients was determined, and the predominant contribution of zwitterionic species to the overall lipophilicity was experimentally proven for the first time. The compounds studied were the amphoteric eburnane alkaloid cis- and trans-apovincaminic acids of therapeutic interest. Partition of the individual microspecies was mimicked by model compounds of the closest possible similarity, and then correction factors were determined and introduced. The noncharged microspecies of the cis-epimer is 30 900 times as lipophilic as its zwitterionic protonation isomer, while the analogous ratio for the trans-epimer is around 15 800. Due to the overwhelming dominance of the zwitterionic form, however, its contribution to the overall lipophilicity exceeds 8 and 5 times that of the noncharged form for the two epimers, respectively. The lipophilicity profile of these zwitterionic compounds is expressed, calculated, and depicted in terms of species-specific lipophilicities over the entire pH range.
dc.format.extent 6942-6947
dc.relation.ispartof urn:issn:0022-2623
dc.title Zwitterions Can Be Predominant in Membrane Penetration of Drugs: Experimental Proof
dc.type Journal Article 2023-05-11T07:12:21Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 2112763
dc.identifier.wos 000307264100025
dc.identifier.pubmed 22793155
dc.contributor.institution Gyógyszerészi Kémiai Intézet
dc.mtmt.swordnote Funding Agency and Grant Number: TAMOP [4.2.1.B-09/1/KMR]; National Research Fund of Hungary, OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [T 73804] Funding text: This work was supported by TAMOP Grant 4.2.1.B-09/1/KMR and the National Research Fund of Hungary, OTKA, Grant T 73804.

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