Determination of microscopic acid–base parameters from NMR–pH titrations

dc.contributor.author	Szakács, Zoltán
dc.contributor.author	Kraszni, Márta
dc.contributor.author	Noszál, Béla
dc.date.accessioned	2023-07-05T10:43:50Z
dc.date.available	2023-07-05T10:43:50Z
dc.date.issued	2004
dc.identifier	4444260564
dc.identifier.citation	journalVolume=378;journalIssueNumber=6;journalTitle=ANALYTICAL AND BIOANALYTICAL CHEMISTRY;pagerange=1428-1448;journalAbbreviatedTitle=ANAL BIOANAL CHEM;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/9448
dc.identifier.uri	doi:https://doi.org/10.1007/s00216-003-2390-3
dc.description.abstract	The theory and practice of proton microspeciation based on NMR–pH titrations are surveyed. Principles of bi-, tri-, tetra-, and n-protic microequilibrium systems are discussed. Evaluation methods are exemplified by case studies on bi- and tetraprotic biomolecules. Selection criteria and properties of reporter NMR nuclei are described. Literature data on complete microspeciations of small ligands and site-specific basicity characterizations of peptides and proteins are critically reviewed.
dc.format.extent	1428-1448
dc.relation.ispartof	urn:issn:1618-2642
dc.title	Determination of microscopic acid–base parameters from NMR–pH titrations
dc.type	Journal Article
dc.date.updated	2023-05-11T14:15:24Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	1076324
dc.identifier.wos	000220661800008
dc.identifier.pubmed	15214406
dc.contributor.institution	Gyógyszerészi Kémiai Intézet
dc.contributor.institution	Kémia Doktori Iskola
dc.contributor.institution	Anyag- és Környezetkémiai Intézet
dc.mtmt.swordnote	Megjegyzés-21960124 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-21962091 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-21963027 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-21966206 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-21966443 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-21966870 Chemicals/CAS: protein, 67254-75-5; proton, 12408-02-5, 12586-59-3; Ligands; Peptides; Proteins; Protons Megjegyzés-23008316 Megjegyzés-21541323 Z9: 37 WC: Biochemical Research Methods; Chemistry, Analytical