dc.contributor.author |
Szijártó Attila |
|
dc.contributor.author |
Czigány Zoltán |
|
dc.contributor.author |
Turóczi Zsolt |
|
dc.contributor.author |
Harsányi László |
|
dc.date.accessioned |
2015-01-10T08:26:06Z |
|
dc.date.available |
2015-01-10T08:26:06Z |
|
dc.date.issued |
2012 |
|
dc.identifier |
84869090129 |
|
dc.identifier.citation |
pagination=797-806;
journalVolume=178;
journalIssueNumber=2;
journalTitle=JOURNAL OF SURGICAL RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/973 |
|
dc.identifier.uri |
doi:10.1016/j.jss.2012.06.067 |
|
dc.description.abstract |
Interruption of blood flow can cause ischemic reperfusion injury, which sometimes has a fatal outcome. Recognition of the phenomenon known as reperfusion injury has led to initial interventional approaches to lessen the degree of damage. A number of efficient pharmacologic agents and surgical techniques (e.g., local ischemic preconditioning and postconditioning) are available. A novel, alternative approach to target organ protection is remote ischemic conditioning triggered by brief repetitive ischemia and reperfusion periods in distant organs. Among the different surgical techniques is so-called remote ischemic perconditioning, a method that applies short periods of ischemic reperfusion to a distant organ delivered during target organ ischemia. Although ischemic reperfusion injury is reduced by this technique, the explanation for this phenomenon is still unclear, and approximately only a dozen reports on the topic have appeared in the literature. In our study, therefore, we investigated the connective mechanisms, signal transduction, and effector mechanisms behind remote perconditioning, with a review on molecular background and favorable effects. In addition, we summarize the various treatment protocols and models to promote future experimental and clinical research. |
|
dc.relation.ispartof |
urn:issn:0022-4804 |
|
dc.title |
Remote ischemic perconditioning-a simple, low-risk method to decrease ischemic reperfusion injury: Models, protocols and mechanistic background. A review |
|
dc.type |
Journal Article |
|
dc.date.updated |
2015-01-08T10:23:36Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2121799 |
|
dc.identifier.wos |
000311090700046 |
|
dc.identifier.pubmed |
22868050 |
|
dc.contributor.department |
SE/ÁOK/K/I. Sz. Sebészeti Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|