CCK mRNA expression in neuroendocrine CRH neurons is increased in rats subjected to an immune challenge.

CCK mRNA expression in neuroendocrine CRH neurons is increased in rats subjected to an immune challenge.

Juaneda C; Lafon-Dubourg P; Ciofi P; Sarrieau A; Wenger Tibor; Tramu G; Corio M

Folyóiratcikk

BRAIN RESEARCH vol.:901, issue.:1-2, p.:277-280.

ISSN: 0006-8993

URI: http://repo.lib.semmelweis.hu//handle/123456789/1395

MTMT azonosító: 1506958

PubMed ID: 11368978

Megjelenés éve: 2001

Kivonat:

The expression of cholecystokinin (CCK) mRNA in neuroendocrine corticotropin-releasing hormone (CRH) neurons of the hypothalamic paraventricular nucleus (PVN) of male rats was examined 8 h following an acute immune challenge by intraperitoneal lipopolysaccharide (LPS, 250 microg/kg). Both quantitative, macroautoradiographic, single-label radioactive in situ hybridization histochemistry (ISHH) and qualitative dual-label ISHH were performed. Compared to controls, LPS-injected rats displayed increased (185%) parvicellular CCK mRNA expression levels, occurring in a majority (70%) of CRH neurons as revealed by dual-label ISHH.

Teljes nézet