Kivonat:
Aim-To study the effect of folate treatment on hyperhomocysteinaemia
and the effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene
polymorphism on total homocysteine and folate concentrations after
renal transplantation.
Methods-A total of 30 transplanted children and adolescents were
investigated for total homocysteine and folate serum concentrations
before and after folate treatment, as well as for the presence of the
MTHFR C677T polymorphism.
Results-The allele frequency of C677T polymorphism in the MTHFR gene in
the study population (0.33) was not different to that in controls
(0.38). Before folate treatment the homocysteine concentration was
raised in all groups; following folate supplementation it was
significantly decreased in the CC and CT groups, but not in the TT
group. In patients with CC genotype, serum homocysteine correlated with
serum creatinine and cholesterol, and time since transplantation before
treatment.
Conclusion-Folate supplementation appears to be an effective strategy
to normalise total homocysteine concentration in renal transplanted
children and adolescents.
