Kivonat:
In the first part of the review article authors summarize our
knowledge on the role of complement in atherogenesis and the
development of I/R injury as well as the complement activation
products which contribute to these pathological processes. In
the second part of the review authors highlight the complement
dependent processes which participate at the pathomechanism of
cerebrovascular diseases, the development of cerebral infarct in
ischemic stroke and the restenosis which may occur a part of the
patients who underwent eversion endartectomy operation.
Literature data and the recently published data of the authors'
group indicate that the complement system is strongly activated
at the onset of the ischemic stroke and the extent of this
activation is positively correlated with the bad outcome of the
disease. This observation may be one of the starting points of
the introduction of the complement activation-inhibiting therapy
in ischemic stroke.
