tallózása szerző szerint "Bencsik, Péter"

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  • Adverse Effects on beta-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function 
    Schreckenberg R; Bencsik, Péter; Weber M; Abdallah Y; Csonka, Csaba; Gömöri, Kamilla; Kiss, Krisztina; Pálóczi, János; Pipis J; Sárközy, Márta; Ferdinandy, Péter; Schulz R; Schluter KD (2017)
    BACKGROUND: Ischemic preconditioning (IPC) and ischemic postconditioning (IPoC) are currently among the most efficient strategies protecting the heart against ischemia/reperfusion injury. However, the effect of IPC and ...
  • Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide 
    Csonka, Csaba; Kupai, Krisztina; Bencsik, Péter; Görbe, Anikó; Pálóczi, János; Zvara, Ágnes; Puskás, László; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    It has been previously shown that hyperlipidemia interferes with cardioprotective mechanisms. Here we investigated the interaction of hyperlipidemia with cardioprotection induced by pharmacological activators of ATP-sensitive ...
  • Definition of hidden drug cardiotoxicity 
    Ferdinandy, Péter; Baczkó, István; Bencsik, Péter; Giricz, Zoltán; Görbe, Anikó; Pacher, Pál; Varga, Zoltán; Varró, András; Schulz, R (2019)
    Unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Since the original observations in the mid-90s, it has been well established that ...
  • Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection 
    Bencsik, Péter; Kupai, Krisztina; Görbe, Anikó; Kenyeres, Éva; Varga, Zoltán; Pálóczi, János; Gáspár, Renáta; Kovács László; Lutz Weber; Takács Ferenc; Hajdú, István; Fabó Gabriella; Cseh, Sándor; Barna, László; Csont, Tamás; Csonka, Csaba; Dormán, György; Ferdinandy, Péter (2018)
    The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and ...
  • Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet 
    Csont, Tamás Bálint; Sárközy, Márta; Szűcs, Gergő; Szűcs, Csilla; Barkányi, Judit; Bencsik, Péter; Gáspár, Renáta; Földesi, Imre; Csonka, Csaba; Kónya, Csaba; Ferdinandy, Péter (2013)
    BACKGROUND: Although complex multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in hyperlipidemia ...
  • Effect of nitric oxide deficiency on the pulmonary PTHrP system 
    Brockhoff B; Schreckenberg R; Forst S; Heger J; Bencsik, Péter; Kiss, Krisztina; Ferdinandy, Péter; Schulz R; Schluter KD (2017)
    Nitric oxide (NO) deficiency is common in pulmonary diseases, but its effect on pulmonary remodelling is still controversial. As pulmonary parathyroid hormone-related protein (PTHrP) expression is a key regulator of pulmonary ...
  • Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification 
    Varga, Zoltán; Giricz, Zoltán; Bencsik, Péter; Rosalinda Madonna; Gyöngyösi Mariann; Rainer Schulz; Manuel Mayr; Thomas Thum; Puskás, László; Ferdinandy, Péter (2015)
    Ischemic heart disease including myocardial infarction is developing on the basis of several risk-factors and co-morbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the ...
  • Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model 
    Kemény, Ágnes; Csekő, Kata; Szitter, István; Varga, Zoltán; Bencsik, Péter; Kiss, Krisztina; Halmosi, Róbert; Deres, László; Erős, Krisztián; Perkecz A; Kereskai, László; Horváthné László, Terézia; Kiss T; Ferdinandy, Péter; Helyes, Zsuzsanna (2017)
    Cigarette smoke-triggered inflammatory cascades and consequent tissue damage are the main causes of chronic obstructive pulmonary disease (COPD). There is no effective therapy and the key mediators of COPD are not identified ...
  • Ischemic postconditioning alters the gene expression pattern of the ischemic heart 
    Csonka, Csaba; Szűcs, Gergő; Varga-Orvos, Zoltán; Bencsik, Péter; Csont, Tamás Bálint; Zvara, Ágnes; Puskás, László; Ferdinandy, Péter (2014)
    To profile changes in gene expression in response to ischemic postconditioning, isolated rat hearts were subjected to 30 min of regional ischemia followed by 120 min of reperfusion with or without postconditioning. At the ...
  • JDP2 overexpression provokes cardiac dysfunction in mice 
    Heger J; Bornbaum J; Wurfel A; Hill C; Brockmann N; Gáspár, Renáta; Pálóczi, János; Varga, Zoltán; Sárközy, Márta; Bencsik, Péter; Csont, Tamás Bálint; Török, Szilvia; Kojonazarov B; Schermuly RT; Bongler K; Parahuleva M; Ferdinandy, Péter; Schulz R; Euler G (2018)
    The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing ...
  • Lack of Contribution of p66shc and Its Mitochondrial Translocation to Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Preconditioning 
    Boengler K; Bencsik, Péter; Pálóczi, János; Kiss, Krisztina; Pipicz, Márton; Pipis J; Ferdinandy, Péter; Schluter KD; Schulz R (2017)
    Whereas high amounts of reactive oxygen species (ROS) contribute to cardiac damage following ischemia and reperfusion (IR), low amounts function as trigger molecules in the cardioprotection by ischemic preconditioning ...
  • Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart 
    Pipicz, Márton; Kocsis-Fodor, Gabriella; Sarvary-Arantes L; Bencsik, Péter; Varga, Zoltán; Ferdinandy, Péter; Csont, Tamás Bálint (2017)
    Administration of low-dose endotoxin (lipopolysaccharide, LPS) 24 h before a lethal ischemia induces pharmacological late preconditioning. The exact mechanism of this phenomenon is not clear. Here we aimed to investigate ...
  • Measurement of NO in biological samples 
    Csonka, Csaba; Páli, Tibor; Bencsik, Péter; Görbe, Anikó; Ferdinandy, Péter; Csont, Tamás Bálint (2015)
  • Mechanism and consequences of the shift in cardiac arginine metabolism following ischaemia and reperfusion in rats 
    Schreckenberg R; Weber P; Cabrera-Fuentes HA; Steinert I; Preissner KT; Bencsik, Péter; Sárközy, Márta; Csonka, Csaba; Ferdinandy, Péter; Schulz R; Schluter KD (2015)
    Cardiac ischaemia and reperfusion leads to irreversible injury and subsequent tissue remodelling. Initial reperfusion seems to shift arginine metabolism from nitric oxide (NO) to polyamine formation. This may limit functional ...
  • MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart 
    Varga, Zoltán; Kupai, Krisztina; Szűcs, Gergő; Gáspár, Renáta; Pálóczi, János; Faragó, Nóra; Zvara, Ágnes; Puskás, László; Rázga, Zsolt; Tiszlavicz, László; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Ferdinandy, Péter; Csont, Tamás Bálint (2013)
    Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether ...
  • MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs 
    Varga, Zoltán; Zvara, Ágnes; Faragó, Nóra; Kocsis-Fodor, Gabriella; Pipicz, Márton; Gáspár, Renáta; Bencsik, Péter; Görbe, Anikó; Csonka, Csaba; Puskás, László; Thum T; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to i) time-matched non-ischemic ...
  • MMP Activity Detection in Zymograms 
    Bencsik, Péter; Bartekova M; Görbe, Anikó; Kiss, Krisztina; Pálóczi, János; Szűcs, Gergő; Ferdinandy, Péter (2017)
    Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative tool for determining the activity of different MMP isoenzymes in a variety of biological ...
  • Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective 
    Bencsik, Péter; Pálóczi, János; Kocsis-Fodor, Gabriella; Pipis, Judit; Belecz, István; Varga, Zoltán; Csonka, Csaba; Görbe, Anikó; Csont, Tamás Bálint; Ferdinandy, Péter (2014)
    Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered ...
  • Multiple impairments of cutaneous nociceptor function induced by cardiotoxic doses of Adriamycin in the rat 
    Boros, Krisztina; Jancsó, Gábor; Dux, Mária; Fekécs, Zoltán; Bencsik, Péter; Oszlács, Orsolya; Jancsó Gáborné Katona, Márta; Ferdinandy, Péter; Nógrádi, Antal; Sántha, Péter (2016)
    Besides their deleterious action on cardiac muscle, anthracycline-type cytostatic agents exert significant neurotoxic effects on primary sensory neurons. Since cardiac sensory nerves confer protective effects on heart ...
  • Myocardial postconditioning is lost in vascular nitrate tolerance 
    Fekete V; Murlasits, Zsolt; Aypar E; Bencsik, Péter; Sárközy, Márta; Szénási, Gábor; Ferdinandy, Péter; Csont, Tamás Bálint (2013)
    Organic nitrates play an important role in the therapy of ischemic heart disease, however, their clinical application is limited by the development of vascular nitrate tolerance. We have previously shown attenuation of the ...