PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion

PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion

Kántor Orsolya; Molnár Judith; Arimura A; Köves Katalin

Folyóiratcikk

PEPTIDES vol.:21, issue.:6, p.:817-820.

ISSN: 0196-9781

URI: http://repo.lib.semmelweis.hu//handle/123456789/1417
http://dx.doi.org/10.1016/S0196-9781(00)00214-X

MTMT azonosító: 1871389

WoS ID: 000089066400010

PubMed ID: 10959003

Megjelenés éve: 2000

Kivonat:

The effect of PACAP38 on the LH surge and ovulation was compared with that of PACAP27 and VIP in the same model. The peptides were administered intracerebroventricularly before the critical period of the proestrous stage. PACAP38 was able to inhibit ovulation and to prevent the preovulatory LH surge; however, PACAP27 did not inhibit the ovulation and VIP inhibited the ovulation in 2/11 animals. In those animals of the last two groups in which ovulation occurred, the preovulatory LH surge was higher than in control rats. It is speculated that the opposite effect of PACAP38 and PACAP27 on the preovulatory LH surge and ovulation is possibly mediated through different receptors.

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