Drug delivery is a cascade of molecular migration processes, in which the active principle dissolves in and partitions between several biological media of various hydrophilic and lipophilic character. Membrane penetration ...
The molecular constituents of Cirsium brachycephalum fruits were identified, quantified and isolated for the first time. The lignan glycoside tracheloside was the main compound, which was transformed quantitatively into ...
In Jurinea mollis fruit, the dibenzylbutyrolactone-type lignan glycoside arctiin and its aglycone arctigenin were determined for the first time using a combination of optimized enzymatic treatment and complementary ...
Sohajda, Tamás; Hu W H,; Zeng L L,; Li H,; Szente, Lajos; Noszál, Béla; Béni, Szabolcs(2011)
An aqueous capillary electrophoretic method was developed for chiral analysis of the novel anti-diabetic drug, sitagliptin. The acid-base profiling of the analyte was carried out using both capillary electrophoresis and ...
The analysis of highly polar (often charged) compounds which lack a strong UV absorbing chromophore is really challenging. Despite the numerous analytical methods published, the demand for a simple, robust and cheap technique ...
Identification, quantification and isolation of lignans (Lig-s: arctiin, arctigenin and matairesinol) and sesquilignans (SLig-s: lappaol A, isolappaol A, lappaol C and isolappaol C), in Cnicus benedictus L. fruit (CBfr) ...
Szabó, Zoltán István; Szőcs, Levente; Horváth, Péter; Komjati, B; Nagy, József; Janoska, A; Muntean, DL; Noszál, Béla; Tóth, Gergő(2016)
A sensitive and validated liquid chromatography with mass spectrometry method was developed for the enantioseparation of the racemic mixture of pomalidomide, a novel, second-generation immunomodulatory drug, using ...
Aminomorphinans are a relatively young class of opioid drugs among which substances of high in vitro efficacy and favorable in vivo action are found. We report the synthesis and pharmacological evaluation of novel ...