Folyóiratcikkek tallózása szerző szerint "SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika"

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  • Incidence; Paris Classification and follow-up in a nationwide; incident cohort of pediatric patients with inflammatory bowel disease 
    Müller, Katalin Eszter; Lakatos, Péter László; Arató, András; Kovács JB; Herczegné Várkonyi, Ágnes; Szűcs D; Szakos E; Sólyom E; Kovács M; Polgár M; Nemes, Éva; Guthy I; Tokodi I; Tóth, Gergely Péter; Horváth A; Tárnok, András; Csoszánszki, Noémi; Balogh M; Vass, Noémi; Bódi P; Dezsőfi, Antal; Gárdos, László; Micskey, Éva; Papp, Mária; Cseh, Áron; Szabó, Dolóresz; Vörös, Péter; Hungarian IBD Registry Group (HUPIR); Veres, Gábor (2013)
    OBJECTIVES: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian ...
  • Increased heat shock protein 72 expression in celiac disease 
    Sziksz, Erna; Veres, Gábor; Vannay, Ádám; Prókai, Ágnes; Gál, Krisztina; Ónody, Anna; Korponay-Szabó, Ilma Rita; Reusz, György; Szabó, András; Tulassay, Tivadar; Arató, András; Szebeni, Beáta (2010)
    BACKGROUND AND OBJECTIVES: Heat shock protein (HSP) 72, a known chaperone, has potential epithelial barrier protecting, antiapoptotic, and immune system regulatory effects; therefore, our aim was to study its involvement ...
  • Increased synthesis of vascular endothelial growth factor in allergic airway inflammation in histidine decarboxylase knockout (HDC-/-) mice 
    Sziksz, Erna; Kozma, Gergely Tibor; Komlósi, Zsolt; Pállinger, Éva; Kardos, Magdolna; Szebeni, Beáta; Losonczy, György; Falus, András; Szabó, András; Tulassay, Tivadar; Vannay, Ádám (2010)
    Histamine and vascular endothelial growth factor (VEGF) have been implicated in the pathogenesis of allergic asthma; they enhance inflammation, vascular permeability, and mucus secretion. Histamine was suggested to alter ...
  • Independent validation of induced overexpression efficiency across 242 experiments shows a success rate of 39% 
    Munkácsy Gyöngyi; Herman Péter; Győrffy, Balázs (2019)
    Although numerous studies containing induced gene expression have already been published, independent authentication of their results has not yet been performed. Here, we utilized available transcriptomic data to validate ...
  • Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer 
    Merino VF; Cho S; Nguyen N; Sadik H; Narayan A; Talbot C Jr; Cope L; Zhou XC; Zhang Z; Győrffy, Balázs; Sukumar S (2018)
    Background: A combination of entinostat, all-trans retinoic acid, and doxorubicin (EAD) induces cell death and differentiation and causes significant regression of xenografts of triple-negative breast cancer (TNBC). Methods: ...
  • Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival 
    Zhai L; Ladomersky E; Lauing KL; Wu M; Genet M; Gritsina G; Győrffy, Balázs; Brastianos PK; Binder D; Sosman JA; Giles FJ; James CD; Horbinski C; Stupp R; Wainwright DA (2017)
    PURPOSE: Indoleamine 2,3 dioxygenase 1 (IDO1) mediates potent immunosuppression in multiple preclinical models of cancer. However, the basis for elevated IDO1 expression in human cancer, including the most common primary ...
  • Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis 
    Singh P; Jenkins LM; Horst B; Alers V; Pradhan S; Kaur P; Srivastava T; Hempel N; Győrffy, Balázs; Broude EV; Lee NY; Mythreye K (2018)
    Inhibin is a heterodimeric TGF beta family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the a ...
  • Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer 
    McDermott MS; Chumanevich AA; Lim CU; Liang J; Chen M; Altilia S; Oliver D; Rae JM; Shtutman M; Kiaris H; Győrffy, Balázs; Roninson IB; Broude EV (2017)
    Hormone therapy targeting estrogen receptor (ER) is the principal treatment for ER-positive breast cancers. However, many cancers develop resistance to hormone therapy while retaining ER expression. Identifying new druggable ...
  • In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia 
    Gézsi, András; Lautner-Csorba, Orsolya; Erdélyi, Dániel; Hullám, Gábor István; Antal, Péter; Semsei, Ágnes F; Kutszegi, Nóra; Hegyi, Márta; Csordas, Katalin; Kovács, Gábor; Szalai, Csaba (2015)
    CYP3A4 has an important role in the metabolisms of many drugs used in acute lymphoblastic leukemia (ALL) therapy; still, there are practically no publications about the role of CYP3A4 polymorphisms in ALL pharmacogenomics. ...
  • Inoperábilis agytumorok sugárkezelése gyermekkorban 
    Kocsis B; Pap L; Székely, Gábor; Garami, Miklós (2005)
    STUDY OBJECTIVE: Description and evaluation of radiotherapy of inoperable tumours of central nervous system. New possibilities in radiotherapy planning. MATERIALS AND METHODS: Between 1987 and 2004, 58 patients (30 ...
  • Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden 
    Budczies Jan; Seidel Anja; Christopoulos Petros; Endris Volker; Kloor Matthias; Győrffy, Balázs; Seliger Barbara; Schirmacher Peter; Stenzinger Albrecht; Denkert Carsten (2018)
    Harnessing the immune system by checkpoint blockade has greatly expanded the therapeutic options for advanced cancer. Since the efficacy of immunotherapies is influenced by the molecular make-up of the tumor and its crosstalk ...
  • Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors 
    Torchia, Jonathon; Golbourn, Brian; Feng, Shengrui; Ho, King Ching; Sin-Chan, Patrick; Alexandre, Vasiljevic; Joseph, D Norman; Paul, Guilhamon; Livia, Garzia; Natalia, R Agamez; Mei, Lu; Tiffany, S Chan; Daniel, Picard; Pasqualino, de Antonellis; Dong-Anh, Khuong-Quang; Aline, C Planello; Constanze, Zeller; Dalia, Barsyte-Lovejoy; Lucie, Lafay-Cousin; Louis, Letourneau; Mathieu, Bourgey; Man, Yu; Deena, MA Gendoo; Misko, Dzamba; Mark, Barszczyk; Tiago, Medina; Alexandra, N Riemenschneider; A Sorana, Morrissy; Young-Shin, Ra; Vijay, Ramaswamy; Marc, Remke; Christopher, P Dunham; Stephen, Yip; Ho-Keung, Ng; Jian-Qiang, Lu; Vivek, Mehta; Vivek, Mehta; Steffen, Albrecht; Jose, Pimentel; Jennifer, A Chan; Gino, R Somers; Claudia, C Faria; Lucia, Roque; Maryam, Fouladi; Lindsey, M Hoffman; Andrew, S Moore; Yin, Wang; Seung, Ah Choi; Jordan, R Hansford; Daniel, Catchpoole; Diane, K Birks; Nicholas, K Foreman; Doug, Strother; Álmos, Klekner; László, Bognár; Garami, Miklós; Hauser, Péter; Hortobágyi, Tibor; Beverly, Wilson; Juliette, Hukin; Anne-Sophie, Carret; Timothy, E Van Meter; Eugene, I Hwang; Amar, Gajjar; Shih-Hwa, Chiou; Hideo, Nakamura; Helen, Toledano; Iris, Fried; Daniel, Fults; Takafumi, Wataya; Chris, Fryer; David, D Eisenstat; Katrin, Scheinemann; Adam, J Fleming; Donna, L Johnston; Jean, Michaud; Shayna, Zelcer; Robert, Hammond; Samina, Afzal; David, A Ramsay; Nongnuch, Sirachainan; Suradej, Hongeng; Noppadol, Larbcharoensub; Richard, G Grundy; Rishi, R Lulla; Jason, R Fangusaro; Harriet, Druker; Ute, Bartels; Ronald, Grant; David, Malkin; C Jane, McGlade; Theodore, Nicolaides; Tarik, Tihan; Joanna, Phillips; Jacek, Majewski; Alexandre, Montpetit; Guillaume, Bourque; Gary, D Bader; Alyssa, T Reddy; G Yancey, Gillespie; Monika, Warmuth-Metz; Stefan, Rutkowski; Uri, Tabori; Mathieu, Lupien; Michael, Brudno; Ulrich, Sch€uller; Torsten, Pietsch; Alexander, R Judkins; Cynthia, E Hawkins; Eric, Bouffet; Seung-Ki, Kim; Peter, B Dirks; Michael, D Taylor; Anat, Erdreich-Epstein; Cheryl, H Arrowsmith; Daniel, D De Carvalho; James, T Rutka; Nada, Jabado; Annie, Huang (2016)
    We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained ...
  • Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer 
    Bottai G; Diao L; Baggerly KA; Paladini L; Győrffy, Balázs; Raschioni C; Pusztai L; Calin GA; Santarpia L (2017)
    MicroRNAs (miRNAs) simultaneously modulate different oncogenic networks, establishing a dynamic system of gene expression and pathway regulation. In this study, we analyzed global miRNA and messenger RNA (mRNA) expression ...
  • Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities 
    Stires H; Heckler MM; Fu X; Li Z; Grasso CS; Quist MJ; Lewis JA; Klimach U; Zwart A; Mahajan A; Győrffy, Balázs; Cavalli LR; Riggins RB (2018)
    Invasive lobular breast cancer (ILC) is an understudied malignancy with distinct clinical, pathological, and molecular features that distinguish it from the more common invasive ductal carcinoma (IDC). Mounting evidence ...
  • Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002 
    Stary Jan; Zimmermann Martin; Campbell Myriam; Castillo Luis; Dibar Eduardo; Svetlana Donska; Alejandro Gonzalez; Shai Izraeli; Dragana Janic; Janez Jazbec; Josip Konja; Emilia Kaiserova; Jerzy Kowalczyk; Kovács, Gábor; Chi-Kong Li; Edina Magyarosy; Alexander Popa; Batia Stark; Yahia Jabali; Jan Trka; Ondrej Hrusak; Hansjörg Riehm; Giuseppe Masera; Martin Schrappe (2014)
    PURPOSE: From 2002 to 2007, the International Berlin-Frankfurt-Munster Study Group conducted a prospective randomized clinical trial (ALL IC-BFM 2002) for the management of childhood acute lymphoblastic leukemia (ALL) in ...
  • Intertumoral Heterogeneity within Medulloblastoma Subgroups 
    Cavalli, FMG; Remke, M; Rampasek, L; Peacock, J; Shih, DJH; Luu, B; Garzia, L; Torchia, J; Nor, C; Morrissy, AS; Agnihotri, S; Thompson, YY; Kuzan-Fischer, CM; Farooq, H; Isaev, K; Daniels, C; Cho, BK; Kim, SK; Wang, KC; Lee, JY; Grajkowska, WA; Perek-Polnik, M; Vasiljevic, A; Faure-Conter, C; Jouvet, A; Giannini, C; Rao, AAN; Li, KKW; Ng, HK; Eberhart, CG; Pollack, IF; Hamilton, RL; Gillespie, GY; Olson, JM; Leary, S; Weiss, WA; Lach, B; Chambless, LB; Thompson, RC; Cooper, MK; Vibhakar, R; Hauser, Péter; van Veelen, MLC; Kros, JM; French, PJ; Ra, YS; Kumabe, T; Lopez-Aguilar, E; Zitterbart, K; Sterba, J; Finocchiaro, G; Massimino, M; Van, Meir EG; Osuka, S; Shofuda, T; Klekner, Álmos; Zollo, M; Leonard, JR; Rubin, JB; Jabado, N; Albrecht, S; Mora, J; Van, Meter TE; Jung, S; Moore, AS; Hallahan, AR; Chan, JA; Tirapelli, DPC; Carlotti, CG; Fouladi, M; Pimentel, J; Faria, CC; Saad, AG; Massimi, L; Liau, LM; Wheeler, H; Nakamura, H; Elbabaa, SK; Perezpeña-Diazconti, M; Chico Ponce de León, F; Robinson, S; Zapotocky, M; Lassaletta, A; Huang, A; Hawkins, CE; Tabori, U; Bouffet, E; Bartels, U; Dirks, PB; Rutka, JT; Bader, GD; Reimand, J; Goldenberg, A; Ramaswamy, V; Taylor, MD (2017)
    While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene ...
  • Intravenous dosing of tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis 
    Mallalieu, Navita L; Wimalasundera, Sunethra; Hsu, Joy C; Douglass, Wendy; Wells, Chris; Penades, Inmaculada Calvo; Cuttica, Ruben; Huppertz, Hans-Iko; Joos, Rik; Kimura, Yukiko; Milojevic, Diana; Rosenkranz, Margalit; Schikler, Kenneth; Constantin, Tamás; Wouters, Carine (2019)
    The anti-interleukin-6 receptor-alpha antibody tocilizumab was approved for intravenous (IV) injection in the treatment of patients with systemic juvenile idiopathic arthritis (sJIA) aged 2 to 17 years based on results of ...
  • Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis 
    Xue X; Ramakrishnan SK; Weisz K; Triner D; Xie L; Pant A; Attili D; Győrffy, Balázs; Zhan M; Carter-Su C; Hardiman KM; Wang TD; Dame MK; Varani J; Brenner D; Fearon ER; Shah YM (2016)
    Dietary iron intake and systemic iron balance are implicated in colorectal cancer (CRC) development, but the means by which iron contributes to CRC are unclear. Gene expression and functional studies demonstrated that the ...
  • JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression 
    Mohrherr, J; Haber, M; Breitenecker, K; Aigner, P; Moritsch, S; Voronin, V; Eferl, R; Moriggl, R; Stoiber, D; Győrffy, Balázs; Brcic, L; László, V; Döme, Balázs; Moldvay, Judit; Dezső, Katalin; Bilban, M; Popper, H; Moll, HP; Casanova, E (2019)
  • Jumping translocation of 17q11 approximately qter and 3q25 approximately q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia. 
    Haltrich, Irén; Kost-Alimova M; Kovács, Gábor; Kriván, Gergely; Tamaska J; Klein G; Fekete, György; Imreh S (2006)
    The virtually obligatory presence of the Philadelphia chromosome may suggest a causal homogeneity, but chronic myelogenous leukemia (CML) is a clinically heterogeneous disease. This may be a consequence of the variable BCR ...