Folyóiratcikkek tallózása szerző szerint "Giricz, Zoltán"

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  • Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning 
    Baranyai, Tamás; Nagy, Csilla Terézia; Koncsos, Gábor; Onódi, Zsófia; Karolyi-Szabo M; Makkos, András; Varga, Zoltán; Ferdinandy, Péter; Giricz, Zoltán (2015)
    BACKGROUND: Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning ...
  • Alternative Splicing of NOX4 in the Failing Human Heart 
    Varga, Zoltán; Pipicz, Márton; Baán, Júlia Aliz; Baranyai T; Koncsos, Gábor; Leszek P; Kusmierczyk M; Sanchez-Cabo F; Garcia-Pavia P; Brenner, Gábor; Giricz, Zoltán; Csont, Tamás Bálint; Mendler, Luca; Lara-Pezzi E; Pacher, Pál; Ferdinandy, Péter (2017)
    Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. ...
  • Autophagosome formation is required for cardioprotection by chloramphenicol 
    Giricz, Zoltán; Varga, Zoltán; Koncsos, Gábor; Nagy, Csilla Terézia; Görbe, Anikó; Mentzer RM Jr; Gottlieb RA; Ferdinandy, Péter (2017)
    AIMS: Chloramphenicol (CAP), a broad spectrum antibiotic, was shown to protect the heart against ischemia/reperfusion (I/R) injury. CAP also induces autophagy, however, it is not known whether CAP-induced cardioprotection ...
  • Cardiac Nitric Oxide Signalling in Metabolic Syndrome 
    Pechanova O; Varga, Zoltán; Cebova M; Giricz, Zoltán; Pacher, Pál; Ferdinandy, Péter (2015)
    It is well documented that metabolic syndrome (i.e. a group of risk factors, such as abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low cholesterol level in ...
  • Cardioprotection by gene therapy 
    Madonna R; Cadeddu C; Deidda M; Giricz, Zoltán; Madeddu C; Mele D; Monte I; Novo G; Pagliaro P; Pepe A; Spallarossa P; Tocchetti CG; Varga, Zoltán; Zito C; Geng YJ; Mercuro G; Ferdinandy, Péter (2015)
    Ischemic heart disease remains the leading cause of death worldwide. Ischemic pre-, post-, and remote conditionings trigger endogenous cardioprotection that renders the heart resistant to ischemic-reperfusion injury (IRI). ...
  • Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles 
    Giricz, Zoltán; Varga, Zoltán; Baranyai, Tamás; Sipos, Péter; Pálóczi, Krisztina; Kittel, Ágnes; Buzás, Edit Irén; Ferdinandy, Péter (2014)
    Remote ischemic preconditioning (RIPC) of the heart is exerted by brief ischemic insults affected on a remote organ or a remote area of the heart before a sustained cardiac ischemia. To date, little is known about the ...
  • Definition of hidden drug cardiotoxicity 
    Ferdinandy, Péter; Baczkó, István; Bencsik, Péter; Giricz, Zoltán; Görbe, Anikó; Pacher, Pál; Varga, Zoltán; Varró, András; Schulz, R (2019)
    Unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Since the original observations in the mid-90s, it has been well established that ...
  • Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress 
    Koncsos, Gábor; Varga, Zoltán; Baranyai, Tamás; Boengler K; Rohrbach S; Li L; Schluter KD; Schreckenberg R; Radovits, Tamás; Oláh, Attila; Mátyás, Csaba; Lux, Árpád; Al-Khrasani, Mahmoud; Komlódi, Tímea; Bukosza, Éva Nóra; Máthé, Domokos; Deres, László; Bartekova M; Rajtik T; Adameova A; Szigeti, Krisztián; Hamar, Péter; Helyes, Zsuzsanna; Tretter, László; Pacher, Pál; Merkely, Béla Péter; Giricz, Zoltán; Schulz R; Ferdinandy, Péter (2016)
    Although incidence and prevalence of prediabetes are increasing, little is known on its cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac function and to characterize parameters ...
  • Effect of hypercholesterolemia on myocardial function, ischemia-reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning 
    Andreadou I; Iliodromitis EK; Lazou A; Görbe, Anikó; Giricz, Zoltán; Schulz R; Ferdinandy, Péter (2017)
    Hypercholesterolemia is considered to be a principle risk factor for cardiovascular disease, having direct negative effects on the myocardium itself, in addition to the development of atherosclerosis. Since hypercholesterolemia ...
  • Effects of Vitamin D Deficiency on Proliferation and Autophagy of Ovarian and Liver Tissues in a Rat Model of Polycystic Ovary Syndrome 
    Lajtai, Krisztina; Nagy, Csilla Terézia; Tarszabó, Róbert; Benkő, Rita; Hadjadj, Leila; Sziva, Réka Eszter; Gerszi, Dóra; Bányai, Bálint; Ferdinandy, Péter; Nádasy, György László; Giricz, Zoltán; Horváth, Eszter Mária; Várbíró, Szabolcs (2019)
    We aimed to examine the alterations of the insulin signaling pathway, autophagy, nitrative stress and the effect of vitamin D supplementation in the liver and ovaries of vitamin D deficient hyperandrogenic rats.Female ...
  • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) 
    Egea J; Fabregat I; Frapart YM; Ghezzi P; Gorlach A; Kietzmann T; Kubaichuk K; Knaus UG; Lopez MG; Olaso-Gonzalez G; Petry A; Schulz R; Vina J; Winyard P; Abbas K; Ademowo OS; Afonso CB; Andreadou I; Antelmann H; Antunes F; Aslan M; Bachschmid MM; Barbosa RM; Belousov V; Berndt C; Bernlohr D; Bertran E; Bindoli A; Bottari SP; Brito PM; Carrara G; Casas AI; Chatzi A;; Chondrogianni N; Conrad M; Cooke MS; Costa JG; Cuadrado A; My-Chan Dang P; De Smet B; Debelec-Butuner B; Dias IHK; Dunn JD; Edson AJ; El Assar M; El-Benna J; Ferdinandy, Péter; Fernandes AS; Fladmark KE; Forstermann U; Giniatullin R; Giricz, Zoltán; Görbe, Anikó; Griffiths H; Hampl V; Hanf A; Herget J; Hernansanz-Agustin P; Hillion M; Huang J; Ilikay S; Jansen-Durr P; Jaquet V; Joles JA; Kalyanaraman B; Kaminskyy D; Karbaschi M; Kleanthous M; Klotz LO; Korac B; Korkmaz KS; Koziel R; Kracun D; Krause KH; Kren V; Krieg T; Laranjinha J; Lazou A; Li H; Martinez-Ruiz A; Matsui R; McBean GJ; Meredith SP; Messens J; Miguel V; Mikhed Y; Milisav I; Milkovic L; Miranda-Vizuete A; Mojovic M; Monsalve M; Mouthuy PA; Mulvey J; Munzel T; Muzykantov V; Nguyen ITN; Oelze M; Oliveira NG; Palmeira CM; Papaevgeniou N; Pavicevic A; Pedre B; Peyrot F; Phylactides M; Pircalabioru GG; Pitt AR; Poulsen HE; Prieto I; Rigobello MP; Robledinos-Anton N; Rodriguez-Manas L; Rolo AP; Rousset F; Ruskovska T; Saraiva N; Sasson S; Schroder K; Semen K; Seredenina T; Shakirzyanova A; Smith GL; Soldati T; Sousa BC; Spickett CM; Stancic A; Stasia MJ; Steinbrenner H; Stepanic V; Steven S; Tokatlidis K; Tuncay E; Turan B; Ursini F; Vacek J; Vajnerova O; Valentova K; Van Breusegem F; Varisli L; Veal EA; Yalcin AS; Yelisyeyeva O; Zarkovic N; Zatloukalova M; Zielonka J; Touyz RM; Papapetropoulos A; Grune T; Lamas S; Schmidt HHHW; Di Lisa F; Daiber A (2017)
    The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different ...
  • Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology 
    Sluijter JPG; Davidson SM; Boulanger CM; Buzás, Edit Irén; de Kleijn DPV; Engel FB; Giricz, Zoltán; Hausenloy DJ; Kishore R; Lecour S; Leor J; Madonna R; Perrino C; Prunier F; Sahoo S; Schiffelers RM; Schulz R; Van Laake LW; Ytrehus K; Ferdinandy, Péter (2018)
    Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include ...
  • Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification 
    Varga, Zoltán; Giricz, Zoltán; Bencsik, Péter; Rosalinda Madonna; Gyöngyösi Mariann; Rainer Schulz; Manuel Mayr; Thomas Thum; Puskás, László; Ferdinandy, Péter (2015)
    Ischemic heart disease including myocardial infarction is developing on the basis of several risk-factors and co-morbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the ...
  • Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats 
    Bukosza, Eva Nora; Kaucsár, Tamás; Godó, Mária; Lajtár, Enikő; Tod, Pál; Koncsos, Gábor; Varga, Zoltán V; Baranyai, Tamás; Tu, Nguyen Minh; Schachner, Helga; Sőti, Csaba; Ferdinandy, Péter; Giricz, Zoltán; Szénási, Gábor; Hamar, Péter (2019)
    Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and ...
  • Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion 
    Brenner, Gábor B; Makkos, András; Nagy, Csilla Terézia; Onódi, Zsófia; Sayour, Nabil V; Gergely, Tamás G; Kiss, Bernadett; Görbe, Anikó; Sághy, Éva; Zádori, Zoltán Sándor; Lázár, Bernadette; Baranyai, Tamás; Varga, Richárd S; Husti, Zoltán; Varró, András; Tóthfalusi, László; Schulz, Rainer; Baczkó, István; Giricz, Zoltán; Ferdinandy, Péter (2020)
    Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of 'hidden cardiotoxicity' is defined as cardiotoxicity of a ...
  • Hypercholesterolemia downregulates autophagy in the rat heart 
    Giricz, Zoltán; Koncsos, Gábor; Tomáš Rajtík; Varga, Zoltán; Baranyai, Tamás; Csonka, Csaba; Adrián Szobi; Adriana Adameová; Roberta A Gottlieb; Ferdinandy, Péter (2017)
    Background: We have previously shown that efficiency of ischemic conditioning is diminished in hypercholesterolemia and that autophagy is necessary for cardioprotection. However, it is unknown whether isolated hypercholesterolemia ...
  • Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy 
    Varga, Zoltán; Giricz, Zoltán; Liaudet L; Hasko G; Ferdinandy, Péter; Pacher, Pál (2015)
    Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic cardiovascular dysfunction also underscores the development of diabetic retinopathy, nephropathy and neuropathy. Despite the ...
  • Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion 
    Pavo N; Lukovic D; Zlabinger K; Lorant D; Goliasch G; Winkler J; Pils D; Auer K; Ankersmit HJ; Giricz, Zoltán; Sárközy, Márta; Jakab A; Garamvolgyi R; Emmert MY; Hoerstrup SP; Hausenloy DJ; Ferdinandy, Péter; Maurer G; Gyongyosi M (2017)
    We have previously shown that distal anterior wall ischemia/reperfusion induces gene expression changes in the proximal anterior myocardial area, involving genes responsible for cardiac remodeling. Here we investigated the ...
  • In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature 
    Baranyai, Tamás; Giricz, Zoltán; Varga, Zoltán; Koncsos, Gábor; Lukovic D; Makkos, András; Sárközy, Márta; Pavo N; Jakab A; Czimbalmos, Csilla; Vágó, Hajnalka; Ruzsa, Zoltán; Tóth, Levente; Garamvölgyi, Rita; Merkely, Béla Péter; Schulz R; Gyongyosi M; Ferdinandy, Péter (2017)
    BACKGROUND: Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies ...
  • Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods 
    Baranyai, Tamás; Herczeg K; Onodi Z; Voszka, István; Módos, Károly; Marton, Nikolett; Nagy, György; Mager I; Wood MJ; El Andaloussi S; Pálinkás, Zoltán; Kumar V; Nagy, Péter; Kittel, Ágnes; Buzás, Edit Irén; Ferdinandy, Péter; Giricz, Zoltán (2015)
    BACKGROUND: Exosomes are emerging targets for biomedical research. However, suitable methods for the isolation of blood plasma-derived exosomes without impurities have not yet been described. AIM: Therefore, we investigated ...