Show simple item record Kis, Adrián Eszes, Noémi Tamási, Lilla Losonczy, György Csekeo A Csomor, Judit Müller, Veronika 2016-08-24T14:09:34Z 2016-08-24T14:09:34Z 2013
dc.identifier 84884189158
dc.identifier.citation pagination=235, pages 6; journalVolume=11; journalIssueNumber=1; journalTitle=WORLD JOURNAL OF SURGICAL ONCOLOGY;
dc.identifier.uri doi:10.1186/1477-7819-11-235
dc.description.abstract We report a 52-year-old patient who developed B-cell non-Hodgkin's lymphoma subsequent to sarcoidosis. Sarcoidosis was diagnosed 16 years ago and remained asymptomatic for 14 years after steroid treatment. She presented with new symptoms of arthralgia, photosensitivity, butterfly erythema, autoimmune antibodies (ANA, chromatin positivity) associated with progression of the known left upper lobe lesion on the chest X-ray suggesting primary autoimmune disease (systemic lupus erythematosus). As steroid treatment was not effective, we started bolus cyclophosphamide therapy after which progression was seen on the chest X-ray. Computed tomography (CT)-guided needle biopsy confirmed malignancy of indefinable origin. Despite of the well-known fluorodeoxyglucose (FDG) avidity in active sarcoidosis, a FDG-positron emission tomography (PET) scan was performed to stage the primary tumour. Intensive FDG uptake was detected in the affected lung segment, with moderate uptake in mediastinal lymph nodes. The patient underwent left upper lobectomy. The histology showed pulmonary mucosa-associated lymphoma (bronchus-associated lymphoid tissue (BALT) lymphoma) in the lung tissue, while only sarcoidosis was present in the mediastinal lymph nodes. Bone marrow biopsy was negative.The association between sarcoidosis and lymphoma is known as sarcoidosis lymphoma syndrome, which is a rare disease. PET-CT was helpful in the differentiation of sarcoidosis and malignancy in this patient. It is important to be aware of the risk of lymphoma in sarcoidosis and FDG-PET, used for adequate purpose, can help the diagnosis.
dc.relation.ispartof urn:issn:1477-7819
dc.title Sarcoidosis lymphoma syndrome - the value of PET-CT in the diagnosis
dc.type Journal Article 2015-11-30T12:15:47Z
dc.language.rfc3066 en
dc.identifier.mtmt 2451980
dc.identifier.wos 000325521100001
dc.identifier.pubmed 24047276
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.department SE/AOK/K/Pulmonológiai Klinika
dc.contributor.institution Semmelweis Egyetem

Files in this item



This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account