dc.contributor.author |
Cseprekál, Orsolya |
|
dc.contributor.author |
Kis, Éva PhD |
|
dc.contributor.author |
Schäffer P |
|
dc.contributor.author |
Othmane, Taha |
|
dc.contributor.author |
Fekete BC |
|
dc.contributor.author |
Vannay, Ádám |
|
dc.contributor.author |
Szabó, Attila |
|
dc.contributor.author |
Remport, Ádám |
|
dc.contributor.author |
Szabó, András |
|
dc.contributor.author |
Tulassay, Tivadar |
|
dc.contributor.author |
Reusz, György |
|
dc.date.accessioned |
2017-09-14T12:09:46Z |
|
dc.date.available |
2017-09-14T12:09:46Z |
|
dc.date.issued |
2009 |
|
dc.identifier |
58049221180 |
|
dc.identifier.citation |
pagination=309-315;
journalVolume=24;
journalIssueNumber=1;
journalTitle=NEPHROLOGY DIALYSIS TRANSPLANTATION; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/4254 |
|
dc.identifier.uri |
doi:10.1093/ndt/gfn494 |
|
dc.description.abstract |
Background. Arterial stiffness (ASt) increases with age, a
process accelerated by uraemia and reversed by transplantation
(Tx). Increased ASt results in an elevated pulse wave velocity
(PWV). Methods. To compare the PWV of Tx patients (n = 25, age =
15.1/95% CI = 13.5-16.7/year) and healthy controls, three
control groups were formed: matched for age (A), for height and
weight (H/W) and for age and height (A/H), respectively. To
avoid bias from the growth deficit of Tx, firstly Z-scores of
PWV were calculated (PWV-Z). Second, the PWV/height (PWV/h)
ratio was assessed. Pre-Tx serum Ca, P, PTH and the cumulative
dose of calcitriol (cCTL) were also analysed. Finally, Tx
patients were compared to ESRD patients (n = 11). PWV was
measured by applanation tonometry. Results. Tx were smaller than
A and older than H/W. The PWV of Tx differed only from H/W and
A/H. PWV-Z and PWV/h of Tx were increased compared to all
control groups. They correlated with the CaxP and cCTL before Tx
and were independent of age. Patients with creatinine clearance
> 90 ml/min/1.73 m(2) or < 1 year on dialysis had lower PWV-Z
and PWV/h than ESRD. Conclusion. Controls that matched for both
age and height should be used to assess PWV in children with
growth failure. PWV-Z is a universal age-independent parameter
of PWV in cases of growth retardation; PWV/h is a simple
alternative of PWV-Z. CaxP and cCTL are major determinants of
ASt after Tx. PWV may be reduced after Tx suggesting that the
uraemia-induced cardiovascular changes might be reversible. |
|
dc.relation.ispartof |
urn:issn:0931-0509 |
|
dc.title |
Pulse wave velocity in children following renal transplantation |
|
dc.type |
Journal Article |
|
dc.date.updated |
2017-04-04T11:34:37Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
155290 |
|
dc.identifier.wos |
000261908200046 |
|
dc.identifier.pubmed |
http://www.ncbi.nlm.nih.gov/pubmed/18775897 |
|
dc.contributor.department |
SE/AOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Transzplantációs és Sebészeti Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|