Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.

Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.

Tábi, Tamás; Szökő, Éva; Merey A,; Tóth, Veronika; Mátyus, Péter; Gyires, Klára

Folyóiratcikk

JOURNAL OF NEURAL TRANSMISSION vol.:120, issue.:6, p.:963-967.

ISSN: 0300-9564

URI: http://repo.lib.semmelweis.hu//handle/123456789/557
http://dx.doi.org/10.1007/s00702-012-0961-1

MTMT azonosító: 2197197

WoS ID: 000319433000016

PubMed ID: 23263543

Megjelenés éve: 2013

Kivonat:

SSAO/VAP-1 participates in the accumulation of leukocytes at the site of inflammation. A new SSAO inhibitor, SzV-1287 was demonstrated to inhibit both acute and chronic inflammation in rats more effectively than the known enzyme inhibitor, LJP-1207. Surprisingly, the SSAO activity was not increased, but decreased both in acute and chronic inflammation. Though experiments are in progress to clarify these findings, the enzyme might play a role in the very early phase of inflammation and be inactivated during leukocyte extravasation.

Teljes nézet