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dc.contributor.author Bergman P
dc.contributor.author Ádori Csaba
dc.contributor.author Vas Szilvia
dc.contributor.author Kai-Larsen Y
dc.contributor.author Sarkanen T
dc.contributor.author Cederlund A
dc.contributor.author Agerberth B
dc.contributor.author Julkunen I
dc.contributor.author Horváth Beáta
dc.contributor.author Kostyalik Diána
dc.contributor.author Kalmár Lajos
dc.contributor.author Bagdy György
dc.contributor.author Huutoniemi A
dc.contributor.author Partinen M
dc.contributor.author Hokfelt T
dc.date.accessioned 2014-11-18T20:56:07Z
dc.date.available 2014-11-18T20:56:07Z
dc.date.issued 2014
dc.identifier 84907228036
dc.identifier.citation pagination=E3735-E3744; journalVolume=111; journalIssueNumber=35; journalTitle=PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/573
dc.identifier.uri doi:10.1073/pnas.1412189111
dc.description.abstract Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia. In this study, we searched for autoantibodies related to narcolepsy using a neuroanatomical array: rat brain sections were processed for immunohistochemistry/double labeling using patient sera/cerebrospinal fluid as primary antibodies. Sera from 89 narcoleptic patients, 52 patients with other sleep-related disorders (OSRDs), and 137 healthy controls were examined. Three distinct patterns of immunoreactivity were of particular interest: pattern A, hypothalamic melanin-concentrating hormone and proopiomelanocortin but not hypocretin/orexin neurons; pattern B, GABAergic cortical interneurons; and pattern C, mainly globus pallidus neurons. Altogether, 24 of 89 (27%) narcoleptics exhibited pattern A or B or C. None of the patterns were exclusive for narcolepsy but were also detected in the OSRD group at significantly lower numbers. Also, some healthy controls exhibited these patterns. The antigen of pattern A autoantibodies was identified as the common C-terminal epitope of neuropeptide glutamic acid-isoleucine/alpha-melanocyte-stimulating hormone (NEI/alphaMSH) peptides. Passive transfer experiments on rat showed significant effects of pattern A human IgGs on rapid eye movement and slow-wave sleep time parameters in the inactive phase and EEG theta-power in the active phase. We suggest that NEI/alphaMSH autoantibodies may interfere with the fine regulation of sleep, contributing to the complex pathogenesis of narcolepsy and OSRDs. Also, patterns B and C are potentially interesting, because recent data suggest a relevance of those brain regions/neuron populations in the regulation of sleep/arousal.
dc.relation.ispartof urn:issn:0027-8424
dc.title Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.
dc.type Journal Article
dc.date.updated 2014-11-18T20:54:14Z
dc.language.rfc3066 en
dc.identifier.mtmt 2720063
dc.identifier.wos 000341230800021
dc.identifier.pubmed 25136085
dc.contributor.department SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport
dc.contributor.department SE/GYTK/Gyógyszerhatástani Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote P.Bergman and C.Adori contributed equally to this work.


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