dc.contributor.author |
Paillard, M |
|
dc.contributor.author |
Csordás, G |
|
dc.contributor.author |
Huang, KT |
|
dc.contributor.author |
Várnai, Péter |
|
dc.contributor.author |
Joseph, SK |
|
dc.contributor.author |
Hajnóczky, G |
|
dc.date.accessioned |
2020-03-30T12:54:05Z |
|
dc.date.available |
2020-03-30T12:54:05Z |
|
dc.date.issued |
2018 |
|
dc.identifier |
85056695975 |
|
dc.identifier.citation |
journalVolume=72;journalIssueNumber=4;journalTitle=MOLECULAR CELL;pagerange=778-785.e3;journalAbbreviatedTitle=MOL CELL; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/7337 |
|
dc.identifier.uri |
doi:10.1016/j.molcel.2018.09.008 |
|
dc.description.abstract |
Proper control of the mitochondrial Ca2+ uniporter's pore (MCU) is required to allow Ca2+-dependent activation of oxidative metabolism and to avoid mitochondrial Ca2+ overload and cell death. The MCU's gatekeeping and cooperative activation is mediated by the Ca2+-sensing MICU1 protein, which has been proposed to form dimeric complexes anchored to the EMRE scaffold of MCU. We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU's DIME motif, the selectivity filter. This led us to recognize in MICU1's sequence a putative DIME interacting domain (DID), which is required for both gatekeeping and cooperative activation of MCU and for cell survival. Thus, we propose that MICU1 has to interact with the D-ring formed by the DIME domains in MCU to control the uniporter. Copyright © 2018 Elsevier Inc. All rights reserved. |
|
dc.format.extent |
778-785.e3 |
|
dc.relation.ispartof |
urn:issn:1097-2765 |
|
dc.title |
MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360 |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-07-30T09:57:04Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
30337279 |
|
dc.identifier.wos |
000450187900017 |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|